Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct;35(10):e13332.
doi: 10.1111/jne.13332. Epub 2023 Sep 8.

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for appendiceal neuroendocrine tumours (aNET)

Gregory Kaltsas  1 , Thomas Walter  2 , Ulrich Knigge  3 , Christos Toumpanakis  4 , Ana P Santos  5 , Nehara Begum  6 , Ulrich F Pape  7 , Marco Volante  8 , Andrea Frilling  9 , Anne Couvelard  10
Affiliations

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for appendiceal neuroendocrine tumours (aNET)

Gregory Kaltsas et al. J Neuroendocrinol. 2023 Oct.

Abstract

The aim of the present guidance paper is to update the previous ENETS guidelines on well differentiated appendiceal neuroendocrine tumours (NET), providing practical guidance for the diagnosis and management of appendiceal NET (aNET); poorly differentiated neoplasms are dealt with in a separate guidance paper. This paper is structured on a question-answer format in order to also address controversial issues and areas where uncertainty regarding the management and follow-up of aNET exists. All recommendations are offered on the basis of the best available evidence, along with the authors' experiences in managing these neoplasms. Each recommendation for treatment will provide a level of evidence and grade of recommendation as per the GRADE system (adapted in Infectious Disease Society of United States Public Health Service grading system).

Keywords: appendiceal NET; follow-up; histopathological features; right hemicolectomy; vascular and lymphatic spread.

PubMed Disclaimer

References

REFERENCES

    1. Guyatt GH, Oxman AD, Kunz R, et al. What is “quality of evidence” and why is it important to clinicians? BMJ. 2008;336(7651):995-998.
    1. Toumpanakis C, Fazio N, Tiensuu Janson E, et al. Unmet needs in appendiceal neuroendocrine neoplasms. Neuroendocrinology. 2019;108(1):37-44.
    1. Pape UF, Niederle B, Costa F, et al. ENETS consensus guidelines for neuroendocrine neoplasms of the appendix (excluding goblet cell carcinomas). Neuroendocrinology. 2016;103(2):144-152.
    1. Ribeiro S, De Maeyer F, De Man M, et al. Lessons learned about appendiceal neuroendocrine neoplasms from data analysis of the Belgian Cancer Registry 2010-2015. Acta Gastroenterol Belg. 2021;84(3):458-466.
    1. Holmager P, Willemoe GL, Nielsen K, et al. Neuroendocrine neoplasms of the appendix: characterization of 335 patients referred to the Copenhagen NET Center of Excellence. Eur J Surg Oncol. 2021;47(6):1357-1363.

LinkOut - more resources