Having a blast(oid): Modeling human embryo peri-implantation development with blastoids
- PMID: 37683600
- DOI: 10.1016/j.stem.2023.08.007
Having a blast(oid): Modeling human embryo peri-implantation development with blastoids
Abstract
Studying human embryo development, most particularly around the time of implantation, is a challenge, yet it is necessary to improve assisted reproduction techniques. In this issue, Yu et al.1 and Karvas et al.2 improve integrated stem cell models, called blastoids, to model the peri-implantation human embryo.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests V.P. submitted (through KU Leuven) a patent application relevant to the generation of extraembryonic mesoderm from human naive pluripotent stem cells, filed on August 31, 2022 (EP22193280.9).
Comment on
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3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages.Cell Stem Cell. 2023 Sep 7;30(9):1148-1165.e7. doi: 10.1016/j.stem.2023.08.005. Cell Stem Cell. 2023. PMID: 37683602
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Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk.Cell Stem Cell. 2023 Sep 7;30(9):1246-1261.e9. doi: 10.1016/j.stem.2023.08.002. Cell Stem Cell. 2023. PMID: 37683605
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