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Comment
. 2023 Sep 7;83(17):3046-3048.
doi: 10.1016/j.molcel.2023.08.019.

For the CRISPR Fan(zor)atics: RNA-guided DNA endonucleases discovered in eukaryotes

Constantinos Patinios  1 , Chase L Beisel  2
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For the CRISPR Fan(zor)atics: RNA-guided DNA endonucleases discovered in eukaryotes

Constantinos Patinios et al. Mol Cell. .
Free article

Abstract

RNA-guided DNA endonucleases such as those from CRISPR-Cas systems were considered limited to prokaryotes. Saito et al.1 reveal that distant eukaryotic relatives of Cas nucleases, called Fanzors, also function as RNA-guided DNA endonucleases and can be harnessed for genome editing.

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Conflict of interest statement

Declaration of interests C.L.B. is a co-founder and member of the Scientific Advisory Board for Locus Biosciences as well as a member of the Scientific Advisory Board for Benson Hill.

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