. 2023 Sep 8;23(1):450.

doi: 10.1186/s12887-023-04257-x.

Late preterm birth and growth trajectories during childhood: a linked retrospective cohort study

Yulika Yoshida-Montezuma¹, David Kirkwood², Branavan Sivapathasundaram², Charles D G Keown-Stoneman^{3

4}, Russell J de Souza^{1

5

6}, Teresa To^{3

7

8}, Cornelia M Borkhoff^{3

8

9

10}, Catherine S Birken^{3

8

10

11}, Jonathon L Maguire^{3

4

6

11

12}, Hilary K Brown^{3

7

9

13}, Laura N Anderson^{14

15}; TARGet Kids! Collaboration

Collaborators, Affiliations

Collaborators

TARGet Kids! Collaboration:
Christopher Allen, Danielle D'Annunzio, Mateenah Jaleel, Natricha Levy McFarlane, Jessica A Omand, Sharon Thadani, Mary Aglipay, Imaan Bayoumi, Cornelia M Borkhoff, Sarah Carsley, Alice Charach, Katherine Cost, Curtis D'Hollander, Anne Fuller, Laura Kinlin, Michaela Kucab, Patricia Li, Pat Parkin, Nav Persaud, Sarah Rae, Izabela Socynska, Shelley Vanderhout, Leigh Vanderloo, Peter Wong, Piyumi Konara Mudiyanselage, Xuedi Li, Jenny Liu, Michelle Mitchell, Nusrat Zaffar, Tiffany Bondoc, Trudy-Ann Buckley, Pamela Ruth Flores, Kardelen Kurt, Sangeetha Loganathan, Tarandeep Mali, Laurie Thompson, Jennifer Batten, Jennifer Chan, John Clark, Amy Craig, Kim De Castris-Garcia, Sharon Dharman, Sarah Kelleher, Salimah Nasser, Tammara Pabon, Michelle Rhodes, Rafael Salsa, Julie Skelding, Daniel Stern, Kerry Stewart, Erika Sendra Tavares, Shannon Weir, Maria Zaccaria-Cho, Magdalena Janus, Eric Duku, Caroline Reid-Westoby, Patricia Raso, Amanda Offord, Emy Abraham, Sara Ali, Kelly Anderson, Gordon Arbess, Jillian Baker, Tony Barozzino, Sylvie Bergeron, Gary Bloch, Joey Bonifacio, Ashna Bowry, Caroline Calpin, Douglas Campbell, Sohail Cheema, Brian Chisamore, Evelyn Constantin, Karoon Danayan, Paul Das, Viveka De Guerra, Mary Beth Derocher, Anh Do, Kathleen Doukas, Anne Egger, Allison Farber, Amy Freedman, Sloane Freeman, Sharon Gazeley, Karen Grewal, Charlie Guiang, Curtis Handford, Laura Hanson, Leah Harrington, Sheila Jacobson, Lukasz Jagiello, Gwen Jansz, Paul Kadar, Lukas Keiswetter, Tara Kiran, Holly Knowles, Bruce Kwok, Piya Lahiry, Sheila Lakhoo, Margarita Lam-Antoniades, Eddy Lau, Denis Leduc, Fok-Han Leung, Alan Li, Patricia Li, Roy Male, Aleks Meret, Elise Mok, Rosemary Moodie, Katherine Nash, James Owen, Michael Peer, Marty Perlmutar, Navindra Persaud, Andrew Pinto, Michelle Porepa, Vikky Qi, Noor Ramji, Danyaal Raza, Katherine Rouleau, Caroline Ruderman, Janet Saunderson, Vanna Schiralli, Michael Sgro, Shuja Hafiz, Farah Siam, Susan Shepherd, Cinntha Srikanthan, Carolyn Taylor, Stephen Treherne, Suzanne Turner, Fatima Uddin, Meta van den Heuvel, Thea Weisdorf, Peter Wong, John Yaremko, Ethel Ying, Elizabeth Young, Michael Zajdman, Esmot Ara Begum, Peter Juni, Gurpreet Lakhanpal, Gerald Lebovic, Ifeayinchukwu Shawn Nnorom, Marc Denzel Nunez, Audra Stitt, Kevin Thorpe, Raya Assan, Homa Bondar, George S Charames, Andrea Djolovic, Chelsea Gorscak-Dunn, Mary Hassan, Rita Kandel, Michelle Rodrigues

Affiliations

¹ Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street W, Hamilton, ON, L8S 4L8, Canada.
² ICES, McMaster University, Hamilton, ON, Canada.
³ Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
⁴ Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON, Canada.
⁵ Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
⁶ Population Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, ON, Canada.
⁷ ICES, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
⁸ Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
⁹ Women's College Research Institute, Toronto, ON, Canada.
¹⁰ Division of Pediatric Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
¹¹ Department of Pediatrics, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
¹² Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
¹³ Department of Health & Society, University of Toronto Scarborough, Toronto, ON, Canada.
¹⁴ Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street W, Hamilton, ON, L8S 4L8, Canada. ln.anderson@mcmaster.ca.
¹⁵ Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada. ln.anderson@mcmaster.ca.

PMID: 37684561
PMCID: PMC10485950
DOI: 10.1186/s12887-023-04257-x

Late preterm birth and growth trajectories during childhood: a linked retrospective cohort study

Yulika Yoshida-Montezuma et al. BMC Pediatr. 2023.

. 2023 Sep 8;23(1):450.

doi: 10.1186/s12887-023-04257-x.

Authors

Collaborators

TARGet Kids! Collaboration:
Christopher Allen, Danielle D'Annunzio, Mateenah Jaleel, Natricha Levy McFarlane, Jessica A Omand, Sharon Thadani, Mary Aglipay, Imaan Bayoumi, Cornelia M Borkhoff, Sarah Carsley, Alice Charach, Katherine Cost, Curtis D'Hollander, Anne Fuller, Laura Kinlin, Michaela Kucab, Patricia Li, Pat Parkin, Nav Persaud, Sarah Rae, Izabela Socynska, Shelley Vanderhout, Leigh Vanderloo, Peter Wong, Piyumi Konara Mudiyanselage, Xuedi Li, Jenny Liu, Michelle Mitchell, Nusrat Zaffar, Tiffany Bondoc, Trudy-Ann Buckley, Pamela Ruth Flores, Kardelen Kurt, Sangeetha Loganathan, Tarandeep Mali, Laurie Thompson, Jennifer Batten, Jennifer Chan, John Clark, Amy Craig, Kim De Castris-Garcia, Sharon Dharman, Sarah Kelleher, Salimah Nasser, Tammara Pabon, Michelle Rhodes, Rafael Salsa, Julie Skelding, Daniel Stern, Kerry Stewart, Erika Sendra Tavares, Shannon Weir, Maria Zaccaria-Cho, Magdalena Janus, Eric Duku, Caroline Reid-Westoby, Patricia Raso, Amanda Offord, Emy Abraham, Sara Ali, Kelly Anderson, Gordon Arbess, Jillian Baker, Tony Barozzino, Sylvie Bergeron, Gary Bloch, Joey Bonifacio, Ashna Bowry, Caroline Calpin, Douglas Campbell, Sohail Cheema, Brian Chisamore, Evelyn Constantin, Karoon Danayan, Paul Das, Viveka De Guerra, Mary Beth Derocher, Anh Do, Kathleen Doukas, Anne Egger, Allison Farber, Amy Freedman, Sloane Freeman, Sharon Gazeley, Karen Grewal, Charlie Guiang, Curtis Handford, Laura Hanson, Leah Harrington, Sheila Jacobson, Lukasz Jagiello, Gwen Jansz, Paul Kadar, Lukas Keiswetter, Tara Kiran, Holly Knowles, Bruce Kwok, Piya Lahiry, Sheila Lakhoo, Margarita Lam-Antoniades, Eddy Lau, Denis Leduc, Fok-Han Leung, Alan Li, Patricia Li, Roy Male, Aleks Meret, Elise Mok, Rosemary Moodie, Katherine Nash, James Owen, Michael Peer, Marty Perlmutar, Navindra Persaud, Andrew Pinto, Michelle Porepa, Vikky Qi, Noor Ramji, Danyaal Raza, Katherine Rouleau, Caroline Ruderman, Janet Saunderson, Vanna Schiralli, Michael Sgro, Shuja Hafiz, Farah Siam, Susan Shepherd, Cinntha Srikanthan, Carolyn Taylor, Stephen Treherne, Suzanne Turner, Fatima Uddin, Meta van den Heuvel, Thea Weisdorf, Peter Wong, John Yaremko, Ethel Ying, Elizabeth Young, Michael Zajdman, Esmot Ara Begum, Peter Juni, Gurpreet Lakhanpal, Gerald Lebovic, Ifeayinchukwu Shawn Nnorom, Marc Denzel Nunez, Audra Stitt, Kevin Thorpe, Raya Assan, Homa Bondar, George S Charames, Andrea Djolovic, Chelsea Gorscak-Dunn, Mary Hassan, Rita Kandel, Michelle Rodrigues

Affiliations

¹ Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street W, Hamilton, ON, L8S 4L8, Canada.
² ICES, McMaster University, Hamilton, ON, Canada.
³ Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
⁴ Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON, Canada.
⁵ Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
⁶ Population Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, ON, Canada.
⁷ ICES, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
⁸ Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
⁹ Women's College Research Institute, Toronto, ON, Canada.
¹⁰ Division of Pediatric Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
¹¹ Department of Pediatrics, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
¹² Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
¹³ Department of Health & Society, University of Toronto Scarborough, Toronto, ON, Canada.
¹⁴ Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street W, Hamilton, ON, L8S 4L8, Canada. ln.anderson@mcmaster.ca.
¹⁵ Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada. ln.anderson@mcmaster.ca.

PMID: 37684561
PMCID: PMC10485950
DOI: 10.1186/s12887-023-04257-x

Abstract

Background: Evidence suggests that accelerated postnatal growth in children is detrimental for adult cardiovascular health. It is unclear whether children born late preterm (34-36 weeks) compared to full term (≥ 39 weeks), have different growth trajectories. Our objective was to evaluate the association between gestational age groups and growth trajectories of children born between 2006-2014 and followed to 2021 in Ontario, Canada.

Methods: We conducted a retrospective cohort study of children from singleton births in TARGet Kids! primary care network with repeated measures of weight and height/length from birth to 14 years, who were linked to health administrative databases. Piecewise linear mixed models were used to model weight (kg/month) and height (cm/month) trajectories with knots at 3, 12, and 84 months. Analyses were conducted based on chronological age.

Results: There were 4423 children included with a mean of 11 weight and height measures per child. The mean age at the last visit was 5.9 years (Standard Deviation: 3.1). Generally, the more preterm, the lower the mean value of weight and height until early adolescence. Differences in mean weight and height for very/moderate preterm and late preterm compared to full term were evident until 12 months of age. Weight trajectories were similar between children born late preterm and full term with small differences from 84-168 months (mean difference (MD) -0.04 kg/month, 95% CI -0.06, -0.03). Children born late preterm had faster height gain from 0-3 months (MD 0.70 cm/month, 95% CI 0.42, 0.97) and 3-12 months (MD 0.17 cm/month, 95% CI 0.11, 0.22).

Conclusions: Compared to full term, children born late preterm had lower average weight and height from birth to 14 years, had a slightly slower rate of weight gain after 84 months and a faster rate of height gain from 0-12 months. Follow-up is needed to determine if growth differences are associated with long-term disease risk.

Keywords: Children; Gestational age; Growth trajectory; Height; Late preterm; Weight.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1**
Growth curves for weight in kg per month from 0 to 150 months by gestational age categories. The lines represent the growth curve, and the shaded areas represent the 95% confidence intervals. The box represents a superimposed area of the growth curve between 75 to 150 months

**Fig. 2**
Growth curves for height in cm per month from 0 to 150 months by gestational age categories. The lines represent the growth curve, and the shaded areas represent the 95% confidence intervals. The box represents a superimposed area of the growth curve between 0 to 12 months

**Fig. 3**
Growth curves for weight trajectories in kg per month from 0 to 150 months by sex and gestational age categories. The lines represent the growth curve, and the shaded areas represent the 95% confidence intervals

**Fig. 4**
Growth curves for height trajectories in cm per month from 0 to 150 months by sex and gestational age categories. The lines represent the growth curve, and the shaded areas represent the 95% confidence intervals

See this image and copyright information in PMC

References

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Late preterm birth and growth trajectories during childhood: a linked retrospective cohort study

Collaborators

Affiliations

Late preterm birth and growth trajectories during childhood: a linked retrospective cohort study

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources