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. 1979 Jul;22(7):855-62.
doi: 10.1021/jm00193a020.

2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents

D L Klayman, J F Bartosevich, T S Griffin, C J Mason, J P Scovill

2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents

D L Klayman et al. J Med Chem. 1979 Jul.

Abstract

Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity.

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