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. 2023 Aug 29;24(17):13383.
doi: 10.3390/ijms241713383.

Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania

Luminita-Ioana Iancu Loga  1   2 , Lucia Dican  2   3 , Alin Dan Chiorean  1 , Vlad Florin Chelaru  4 , Florin Ioan Elec  2   5 , Cristina Sorina Catana  3 , Monica Mihaela Marta  4 , Roxana Liana Lucaciu  6 , Adriana Corina Hangan  7 , Cosmina Ioana Bondor  8 , Mihaela Laura Vica  1 , Horea Vladi Matei  1
Affiliations

Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania

Luminita-Ioana Iancu Loga et al. Int J Mol Sci. .

Abstract

End-stage renal disease (ESRD) is the final stage of chronic kidney disease. This study explored the association between human leukocyte antigen (HLA) and ESRD. The interaction between genetic and environmental factors may also play a role in the development of ESRD. The study included 2392 ESRD patients who were awaiting renal transplantation. Blood samples were genotyped by SSOP and SSP-PCR methods. Multivariate logistic regression analysis showed that HLA-A*11 (p = 0.027), HLA-A*34 (p = 0.017), HLA-A*69 (p = 0.012), HLA-B*41 (p < 0.001), HLA-B*50 (p = 0.004), HLA-DRB1*10 (p = 0.027), and HLA-DRB1*14 (p = 0.004) were positively associated with ESRD (OR > 1); HLA-DRB1*07 (p < 0.001), HLA-DRB1*08 (p = 0.005), and HLA-DRB1*13 (p < 0.001) were protective against ESRD (OR < 1); and the three-locus haplotype HLA-A*02-B*41-DRB1*03, containing one susceptible allele, was strongly associated with ESRD (p < 0.001, OR = 3.15). In conclusion, this retrospective analysis of HLA typing in patients with ESRD of various etiologies suggests that molecular data on the HLA polymorphism should be collected in order to identify high-risk ESRD patients and to improve graft survival after kidney transplantation.

Keywords: allele frequency; end-stage renal disease; haplotype frequency; human leukocyte antigen.

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Conflict of interest statement

The authors declare no conflict of interest.

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