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Review
. 2023 Aug 30;24(17):13480.
doi: 10.3390/ijms241713480.

Can Genetic Markers Predict the Sporadic Form of Alzheimer's Disease? An Updated Review on Genetic Peripheral Markers

Danelda Theron  1   2 , Lloyd N Hopkins  2 , Heidi G Sutherland  2 , Lyn R Griffiths  2 , Francesca Fernandez  1   2
Affiliations
Review

Can Genetic Markers Predict the Sporadic Form of Alzheimer's Disease? An Updated Review on Genetic Peripheral Markers

Danelda Theron et al. Int J Mol Sci. .

Abstract

Alzheimer's disease (AD) is the most common form of dementia that affects millions of individuals worldwide. Although the research over the last decades has provided new insight into AD pathophysiology, there is currently no cure for the disease. AD is often only diagnosed once the symptoms have become prominent, particularly in the late-onset (sporadic) form of AD. Consequently, it is essential to further new avenues for early diagnosis. With recent advances in genomic analysis and a lower cost of use, the exploration of genetic markers alongside RNA molecules can offer a key avenue for early diagnosis. We have here provided a brief overview of potential genetic markers differentially expressed in peripheral tissues in AD cases compared to controls, as well as considering the changes to the dynamics of RNA molecules. By integrating both genotype and RNA changes reported in AD, biomarker profiling can be key for developing reliable AD diagnostic tools.

Keywords: Alzheimer’s disease; biomarkers; circular-RNA; genes; long-coding RNA; micro-RNA; peripheral tissues.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Genes involved in neuronal dysfunction in AD pathophysiology.
See this image and copyright information in PMC

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