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Comment
. 2023 Nov 2;69(11):1209-1211.
doi: 10.1093/clinchem/hvad111.

Early and Accurate Diagnosis of Parkinson Disease May Be Rooted in Seed Amplification Assays

Thomas F Tropea  1 , George T Kannarkat  1   2 , Leslie M Shaw  3
Affiliations
Comment

Early and Accurate Diagnosis of Parkinson Disease May Be Rooted in Seed Amplification Assays

Thomas F Tropea et al. Clin Chem. .
No abstract available

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Conflict of interest statement

Authors’ Disclosures or Potential Conflicts of Interest

Upon manuscript submission, all authors completed the author disclosure form.

Figures

Fig. 1.
Fig. 1.
SAA of pathogenic aSyn identifies individuals with and at-risk for PD with high sensitivity. SAA utilizes a “seed” of a pathogenic protein like aSyn from individuals with PD to induce cyclical misfolding and aggregation by repetitive shaking over time. Amplification is detected by accumulation of a fluorescence dye in amyloid-type fibrils. A positive test has accumulation of fluorescence over a specified threshold. In the Siderowf et al. study (3), SAA on CSF from individuals with PD and those with high-risk clinical features and genetic variants demonstrate differing sensitivities but importantly can detect aSyn in living individuals at high-risk for PD. (Created with BioRender.com.)
See this image and copyright information in PMC

Comment on

References

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