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Review
. 2023 Oct:201:115084.
doi: 10.1016/j.addr.2023.115084. Epub 2023 Sep 7.

Up-to-date molecular medicine strategies for management of ocular surface neovascularization

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Free article
Review

Up-to-date molecular medicine strategies for management of ocular surface neovascularization

Yunlong Yang et al. Adv Drug Deliv Rev. 2023 Oct.
Free article

Abstract

Ocular surface neovascularization and its resulting pathological changes significantly alter corneal refraction and obstruct the light path to the retina, and hence is a major cause of vision loss. Various factors such as infection, irritation, trauma, dry eye, and ocular surface surgery trigger neovascularization via angiogenesis and lymphangiogenesis dependent on VEGF-related and alternative mechanisms. Recent advances in antiangiogenic drugs, nanotechnology, gene therapy, surgical equipment and techniques, animal models, and drug delivery strategies have provided a range of novel therapeutic options for the treatment of ocular surface neovascularization. In this review article, we comprehensively discuss the etiology and mechanisms of corneal neovascularization and other types of ocular surface neovascularization, as well as emerging animal models and drug delivery strategies that facilitate its management.

Keywords: Angiogenesis; Animal models; Corneal neovascularization; Drug delivery; Ocular surface.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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