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Randomized Controlled Trial
. 2023 Oct:260:205-208.
doi: 10.1016/j.schres.2023.08.027. Epub 2023 Sep 11.

Augmentation of learning in schizophrenia by d-serine and auditory remediation is related to auditory and frontally-generated biomarkers: A randomized, double-blind, placebo-controlled study

Viraj Govani  1 , Adithya M Shastry  2 , Dan V Iosifescu  3 , Preetika Govil  1 , Megan R Mayer  1 , Tarek Sobeih  4 , Tse-Hwei Choo  2 , Melanie M Wall  2 , Pejman Sehatpour  5 , Joshua T Kantrowitz  6
Affiliations
Randomized Controlled Trial

Augmentation of learning in schizophrenia by d-serine and auditory remediation is related to auditory and frontally-generated biomarkers: A randomized, double-blind, placebo-controlled study

Viraj Govani et al. Schizophr Res. 2023 Oct.
No abstract available

Keywords: Auditory learning; Beta power; NMDA receptor; Oscillations; Schizophrenia; Target engagement.

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Conflict of interest statement

Declaration of competing interest The authors report no relevant interests. Dr. Kantrowitz reports having received consulting payments within the last 24 months from Alphasights, Putnam, techspert.io, Health Monitor, Third Bridge, MEDACorp, Trinity, Globaldata, GKA, Clearview, Clarivate, Health Advances, ECRI Institute, ExpertConnect, Slingshot, Antheum, Guidepoint, First Thought, Wedbush, Jefferies, Otsuka, Vox Neuro and Reckner. He has served on the MedinCell Psychiatry, Merck, Leal and the Karuna Advisory Boards. He has conducted clinical research supported by the NIMH, Sunovion, Roche, Cerevance, Click, Neurocrine, Corcept, Taisho and Boehringer Ingelheim within the last 24 months. He owns a small number of shares of common stock from GSK. Dr. Iosifescu has received consulting honoraria from Alkermes, Allergan, Axsome, Biogen, Centers for Psychiatric Excellence, Jazz, Lundbeck, Otsuka, Precision Neuroscience, Sage, Sunovion; he has received research support (through his academic institutions) from Alkermes, Astra Zeneca, Brainsway, Litecure, Neosync, Otsuka, Roche, and Shire. Drs Sehatpour, Sobeih, Wall, and Mr. Govani, Shastry and Choo and Ms. Mayer and Govil reported no biomedical financial interests or potential conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Top: Time-frequency plots for baseline corrected single-trial power, consisting of 3 main components: 1) sensory responses immediately following the S1 (0–200 ms) and S2 (1000–1200 ms) stimuli; 2) an information ‘retention interval” response that occurs between the S1 and S2 stimuli (400–1000 ms), and 3) a “motor-preparation” interval that occurred following the S2 response (1200–1500 ms). In Aud-Plast, participants were presented with paired tones (e.g., Stimulus 1 (“reference”) and Stimulus 2 (“test”): S1 and S2) and indicate which tone is higher in pitch (frequency, Hz). In the first pair, the between tone ratio was 50 % (e.g. 1000 ± 500 Hz), and the difficulty level was adjusted to maintain a steady (~70 % correct) level of performance with a four-up/one-down staircase procedure. The timing of S1 and S2 presentation, along with β-ERD power during the retention and motor preparation interval are as illustrated. θ, α and β ranges are illustrated. Bottom: Bar graph of β-ERD power during the motor preparation interval, Inset shows topographical plots (headmaps) for β-ERD power at 1340 ms, midpoint of the motor preparation interval. Black circles on headmaps show the ROI, average signal from electrodes Fz, FC1, FC2, and Cz.
Fig. 1.
Fig. 1.
Top: Time-frequency plots for baseline corrected single-trial power, consisting of 3 main components: 1) sensory responses immediately following the S1 (0–200 ms) and S2 (1000–1200 ms) stimuli; 2) an information ‘retention interval” response that occurs between the S1 and S2 stimuli (400–1000 ms), and 3) a “motor-preparation” interval that occurred following the S2 response (1200–1500 ms). In Aud-Plast, participants were presented with paired tones (e.g., Stimulus 1 (“reference”) and Stimulus 2 (“test”): S1 and S2) and indicate which tone is higher in pitch (frequency, Hz). In the first pair, the between tone ratio was 50 % (e.g. 1000 ± 500 Hz), and the difficulty level was adjusted to maintain a steady (~70 % correct) level of performance with a four-up/one-down staircase procedure. The timing of S1 and S2 presentation, along with β-ERD power during the retention and motor preparation interval are as illustrated. θ, α and β ranges are illustrated. Bottom: Bar graph of β-ERD power during the motor preparation interval, Inset shows topographical plots (headmaps) for β-ERD power at 1340 ms, midpoint of the motor preparation interval. Black circles on headmaps show the ROI, average signal from electrodes Fz, FC1, FC2, and Cz.
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References

    1. Ahissar M, Nahum M, Nelken I, Hochstein S, 2009. Reverse hierarchies and sensory learning. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 364 (1515), 285–299. - PMC - PubMed
    1. Barone J, Rossiter HE, 2021. Understanding the role of sensorimotor beta oscillations. Front. Syst. Neurosci. 15, 655886. - PMC - PubMed
    1. Dias EC, Bickel S, Epstein ML, Sehatpour P, Javitt DC, 2013. Abnormal task modulation of oscillatory neural activity in schizophrenia. Front. Psychol. 4, 540. - PMC - PubMed
    1. Donde C, Kantrowitz JT, Medalia A, Saperstein AM, Balla A, Sehatpour P, Martinez A, O’Connell MN, Javitt DC, 2023. Early auditory processing dysfunction in schizophrenia: mechanisms and implications. Neurosci. Biobehav. Rev. 148, 105098. - PMC - PubMed
    1. Fujimoto T, Okumura E, Takeuchi K, Kodabashi A, Tanaka H, Otsubo T, Nakamura K, Sekine M, Kamiya S, Higashi Y, Tsuji M, Shimooki S, Tamura T, 2012. Changes in event-related desynchronization and synchronization during the auditory oddball task in schizophrenia patients. Open Neuroimaging J. 6, 26–36. - PMC - PubMed

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