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. 2024 Oct-Dec;46(4):381-386.
doi: 10.1016/j.htct.2023.07.006. Epub 2023 Aug 28.

Blood components requirement in Brazilian dengue outbreaks: A retrospective analysis between 2008 to 2019

Deivide de Sousa Oliveira  1 , Daniel Girão Britto  2 , Gabriella Fidelis de Sá  2 , Ana Carolina Nogueira Rocha Lima  2 , João Victor Araújo Silva  2 , Antonio Vinícius Barros de Araújo  2 , Rejane Cavalcante Rebelo  2 , Larissa Ciarlini Varandas Sales  2 , Marcus Fábio Tavares de Abreu  2 , Ednardo Ramos de Meneses  2
Affiliations

Blood components requirement in Brazilian dengue outbreaks: A retrospective analysis between 2008 to 2019

Deivide de Sousa Oliveira et al. Hematol Transfus Cell Ther. 2024 Oct-Dec.

Abstract

Introduction: Dengue is the most fatal virus disease spread by mosquito bites and Aedes aegypti is the main transmitting agent. It is an endemic disease in the tropical and subtropical regions, currently affecting more than 100 countries. Although most patients present mild forms of the disease, a considerable proportion of individuals has severe alterations in the blood count. The aim of this study was to evaluate the consumption pattern of blood components in epidemic and non-epidemic periods and to verify if there was an impact on dengue cases and the death rate.

Method: This is a retrospective cross-sectional study conducted through the collection and analysis of data from the Brazilian Ministry of Health from 2008 to 2019 on new cases and deaths from dengue, as well as the consumption of blood components in the period mentioned by hemovigilance bulletins of the Brazilian authority.

Results: Regarding the results, no significant difference was found between the absolute amount of blood components used in years with an epidemic peak. Regarding the relative values, an important variation was shown among the distributive consumption patterns of blood components in the outbreak years. In the univariate linear regression analysis, there was statistical significance between the increase in the number of dengue cases and deaths from dengue with the increase in the consumption of red blood cell concentrates (RBP), platelet concentrates (PP), fresh frozen plasma (FFP) and cryoprecipitate (Cryo) (p-value < 0.05). The increase in dengue cases was related to the increase in Cryo consumption with clinical significance (R² > 0.5), but dengue deaths were not correlated to the same. In multivariate analysis, all regression models had clinical and statistical significance.

Conclusion: The data obtained in the present study demonstrate that there is a relevant relationship between the increase in cases and deaths from dengue with the blood components usage, especially PP, FFP and cryoprecipitate.

Keywords: Blood component; Dengue; Infection; Transfusion.

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Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
LOWESS distribution demonstrating the behaviour of the increase in transfusion requirements in relation to the increase in new DCs. Graph A shows the increase in transfusions in relation to the increase in DC; Graph B shows the increase in transfusions in relation to the increase in cases of death from dengue (DD).
Figure 2
Figure 2
Violin distribution of percentage values of blood components consumption in relation to the presence or absence of an epidemic period.
See this image and copyright information in PMC

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