Chinese Medical Association consensus for standardized diagnosis and treatment of pancreatic neuroendocrine neoplasms

Feng Jiao¹, Jiujie Cui¹, Deliang Fu², Qi Li³, Zheng Wu⁴, Zan Teng⁵, Hongmei Zhang⁶, Jun Zhou⁷, Zhihong Zhang⁸, Xiaobing Chen⁹, Yuhong Zhou¹⁰, Yixiong Li¹¹, Yiping Mou¹², Renyi Qin¹³, Yongwei Sun¹⁴, Gang Jin¹⁵, Yuejuan Cheng¹⁶, Jian Wang¹⁷, Gang Ren¹⁸, Jiang Yue¹⁹, Guangxin Jin²⁰, Xiuying Xiao¹, Liwei Wang¹; Pancreatic Tumor Group, Society of Oncology, Chinese Medical Association

Affiliations

¹ Department of Oncology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
² Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
³ Department of Oncology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China.
⁴ Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710061, China.
⁵ Department of Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110801, China.
⁶ Department of Medical Oncology, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi 710032, China.
⁷ Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China.
⁸ Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
⁹ Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450003, China.
¹⁰ Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
¹¹ Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
¹² Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
¹³ Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
¹⁴ Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
¹⁵ Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
¹⁶ Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
¹⁷ Department of Radiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
¹⁸ Department of Radiotherapy, Peking University Shougang Hospital, Beijing 100144, China.
¹⁹ Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
²⁰ Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

PMID: 37690992
PMCID: PMC10586833
DOI: 10.1097/CM9.0000000000002848

Chinese Medical Association consensus for standardized diagnosis and treatment of pancreatic neuroendocrine neoplasms

Feng Jiao et al. Chin Med J (Engl). 2023.

. 2023 Oct 20;136(20):2397-2411.

doi: 10.1097/CM9.0000000000002848. Epub 2023 Sep 8.

Authors

Affiliations

¹ Department of Oncology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
² Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
³ Department of Oncology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China.
⁴ Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710061, China.
⁵ Department of Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110801, China.
⁶ Department of Medical Oncology, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi 710032, China.
⁷ Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China.
⁸ Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
⁹ Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450003, China.
¹⁰ Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
¹¹ Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
¹² Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
¹³ Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
¹⁴ Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
¹⁵ Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
¹⁶ Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
¹⁷ Department of Radiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
¹⁸ Department of Radiotherapy, Peking University Shougang Hospital, Beijing 100144, China.
¹⁹ Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
²⁰ Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

PMID: 37690992
PMCID: PMC10586833
DOI: 10.1097/CM9.0000000000002848

No abstract available

PubMed Disclaimer

Conflict of interest statement

None.

Figures

**Figure 1**
Process of diagnosis and management of pNENs. pNENs: Pancreatic neuroendocrine neoplasms; F-pNEN: Functionning pancreatic neuroendocrine neoplasm; NF-pNEN: Non-functioning pancreatic neuroendocrine neoplasm.

**Figure 2**
Algorithm for the systemic therapy of pNENs. pNENs: Pancreatic neuroendocrine neoplasms; SSA: Somatostatin analogs; PPI: Proton pump inhibitor; SSTR: Somatostatin receptors; 5-FU: 5-Fluorouracil.

See this image and copyright information in PMC

References

1. Dasari A Shen C Halperin D Zhao B Zhou S Xu Y, et al. . Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol 2017;3: 1335–1342. doi: 10.1001/jamaoncol.2017.0589. - PMC - PubMed
1. Fan JH Zhang YQ Shi SS Chen YJ Yuan XH Jiang LM, et al. . A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in China. Oncotarget 2017;8: 71699–71708. doi: 10.18632/oncotarget.17599. - PMC - PubMed
1. Wu W Jin G Li H Miao Y Wang C Liang T, et al. . The current surgical treatment of pancreatic neuroendocrine neoplasms in China: A national wide cross-sectional study. J Pancreatol 2019;2: 35–42. doi: 10.1097/JP9.0000000000000019.
1. Alvarez MJ Subramaniam PS Tang LH Grunn A Aburi M Rieckhof G, et al. . A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors. Nat Genet 2018;50: 979–989. doi: 10.1038/s41588-018-0138-4. - PMC - PubMed
1. Leoncini E, Carioli G, La Vecchia C, Boccia S, Rindi G. Risk factors for neuroendocrine neoplasms: A systematic review and meta-analysis. Ann Oncol Off J Eur Soc Med Oncol 2016;27: 68–81. doi: 10.1093/annonc/mdv505. - PubMed

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Chinese Medical Association consensus for standardized diagnosis and treatment of pancreatic neuroendocrine neoplasms

Affiliations

Chinese Medical Association consensus for standardized diagnosis and treatment of pancreatic neuroendocrine neoplasms

Authors

Affiliations

Conflict of interest statement

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