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Comment
. 2023 Sep 11;8(1):339.
doi: 10.1038/s41392-023-01592-4.

Targeting copper to combat macrophage-driven inflammation: a potential advanced therapeutic strategy

Ralf Weiskirchen  1
Affiliations
Comment

Targeting copper to combat macrophage-driven inflammation: a potential advanced therapeutic strategy

Ralf Weiskirchen. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
Targeting macrophage-induced inflammation by LCC-12. Macrophage activation is characterized by increased CD44-triggered mitochondrial Cu(II) accumulation and subsequent promotion of NAD(H) cycling. Increased activity of α-ketoglutarate and elevated quantities of nuclear iron trigger metabolic changes and epigenetic modifications leading to inflammatory gene expression. The drug LCC-12 containing two biguanides linked by 12 methylene groups forms specific, highly stable complexes with Cu(II) in mitochondria. The sequestering of Cu(II) by LCC-12 attenuates macrophage activation and dampens inflammatory reactions
See this image and copyright information in PMC

Comment on

  • A druggable copper-signalling pathway that drives inflammation.
    Solier S, Müller S, Cañeque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Pantoș GD, Gandon V, Gaillet C, Wu TD, Dingli F, Loew D, Baulande S, Durand S, Sencio V, Robil C, Trottein F, Péricat D, Näser E, Cougoule C, Meunier E, Bègue AL, Salmon H, Manel N, Puisieux A, Watson S, Dawson MA, Servant N, Kroemer G, Annane D, Rodriguez R. Solier S, et al. Nature. 2023 May;617(7960):386-394. doi: 10.1038/s41586-023-06017-4. Epub 2023 Apr 26. Nature. 2023. PMID: 37100912 Free PMC article.

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