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. 2024 Feb 1;108(2):516-523.
doi: 10.1097/TP.0000000000004801. Epub 2023 Sep 11.

Kidney Donation After Circulatory Death Using Thoracoabdominal Normothermic Regional Perfusion: The Largest Report of the United States Experience

Alice L Zhou  1 , Albert Leng, Jessica M Ruck, Armaan F Akbar, Niraj M Desai, Elizabeth A King
Affiliations

Kidney Donation After Circulatory Death Using Thoracoabdominal Normothermic Regional Perfusion: The Largest Report of the United States Experience

Alice L Zhou et al. Transplantation. .

Abstract

Background: Thoracoabdominal normothermic regional perfusion (TA-NRP) has been increasingly used for donation after circulatory death (DCD) procurements in the United States. We present the largest report of outcomes of kidney transplants performed using DCD donor grafts perfused with TA-NRP.

Methods: Adult DCD kidney transplants between 2020 and 2022 in the United Network for Organ Sharing database were included. Donors with ≥50 min between asystole and aortic cross-clamp time in which the heart was also transplanted were considered TA-NRP donors. All other donors were considered direct recovery donors. Multivariable regressions were used to assess delayed graft function, as well as posttransplant survival and all-cause graft failure at 30, 90, and 180 d. A propensity-matched analysis of cohorts matched on donor Kidney Donor Profile Index was performed.

Results: Of the 16 140 total DCD kidney transplants performed during the study period, 306 (1.9%) used TA-NRP. TA-NRP donors were younger ( P < 0.001) and had lower Kidney Donor Profile Index ( P < 0.001) compared with direct recovery donors. Recipients receiving grafts recovered using TA-NRP were younger ( P < 0.001) and more likely to be blood group O ( P < 0.001). Transplants using TA-NRP had lower likelihood of delayed graft function (adjusted odds ratio 0.22 [95% confidence interval, 0.15-0.31], P < 0.001) but similar 180-d survival ( P = 0.8) and all-cause graft failure ( P = 0.3) as transplants using direct recovery grafts. These inferences were unchanged on propensity-matched analysis.

Conclusions: Our results demonstrate that kidney transplants using TA-NRP DCD allografts have positive short-term mortality and graft survival outcomes, with significantly decreased rates of delayed graft function compared with direct recovery DCD grafts.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1:
Figure 1:
Number of heart and kidney transplants performed from donation after circulatory death (DCD) donors perfused using thoracoabdominal normothermic regional perfusion (TA-NRP) in the United States, 2020 to 2022.
Figure 2:
Figure 2:
All-cause graft failure among kidney transplant recipients receiving TA-NRP vs. direct recovery DCD grafts in the United States, 2020 to 2022. TA-NRP, thoracoabdominal normothermic regional perfusion; HR, hazard ratio; CI, confidence interval.
See this image and copyright information in PMC

References

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