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Editorial
. 2023 May 24;11(2):509-511.
doi: 10.1016/j.gendis.2023.04.003. eCollection 2024 Mar.

Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)

Affiliations
Editorial

Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)

Ke Zhang et al. Genes Dis. .
No abstract available

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Figures

Fig. 1
Figure 1
Schematic of FGF21 accelerating alcohol arousal with a liver-brain axis. Alcohol ingestion promotes liver secretion of FGF21. The increase of FGF21 in endogenous and exogenous manners will activate the noradrenergic KLB+ neurons in the locus coeruleus (LC). The activation of the norepinephrine system coordinates the mice's recovery from alcohol intoxication at last. However, whether the non-noradrenergic KLB+ neurons in LC have a role in anti-alcohol intoxication is still unknown.

References

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