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Review
. 2023 Aug 9;15(8):e43235.
doi: 10.7759/cureus.43235. eCollection 2023 Aug.

MicroRNA Profiling in Circulating Exosomes in Oral Squamous Cell Carcinoma: A Systematic Review

Dinesh Y  1 , Pratibha Ramani  1 , Monal Yuwanati  1 , Karthikeyan Ramalingam  1 , Gheena S  1
Affiliations
Review

MicroRNA Profiling in Circulating Exosomes in Oral Squamous Cell Carcinoma: A Systematic Review

Dinesh Y et al. Cureus. .

Abstract

Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer with several risk factors. Exosomes are extracellular vesicles generated by the fusion of multivesicular structures with the cell membrane and play an important role as intercellular messengers. MicroRNA (miRNA) is a noncoding RNA and regulates post-transcriptional modification. The present systematic review aims to identify and correlate the possible association and role of circulating exosomes with OSCC. Using the search strategy, articles fulfilling the inclusion criteria, published between January 2012 to March 2022, were retrieved from online databases including PubMed, Scopus, Web of Science, and Cochrane Library. About 904 articles were found using an electronic database and a human search. After reviewing the titles and abstracts, 614 studies were eliminated, and duplicate articles were removed. Five studies were included in this systematic review. Circulating exosomal expression of miRNA27, miRNA 21, and miRNA 155 showed significant upregulation in OSCC patients. Circulating exosomes could be potential biomarkers to be used in the detection of patients with OSCC. More studies are warranted in this area to gain a better understanding of the pathophysiology of OSCC and the function of molecular markers from circulating exosomes. Understanding the role of molecular markers from circulating exosomes in pathogenesis will provide a better understanding of the development of the disease, necessitating more study in this area. According to this review, circulating exosomes might be a potential approach to the identification of OSCC.

Keywords: circulating exosomes; microrna; oral potentially malignant disorders; oral squamous cell carcinoma; systematic review.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. PRISMA 2020 flow diagram showing Included articles
Figure 2
Figure 2. Line diagram showing significant fold change in upregulation and downregulation expression of miRNA in OSCC patients
OSCC: oral squamous cell carcinoma
Figure 3
Figure 3. Risk of bias of included study
Figure 4
Figure 4. Risk of bias assessment
See this image and copyright information in PMC

References

    1. Factors related to late stage diagnosis of oral squamous cell carcinoma. Seoane-Romero JM, Vázquez-Mahía I, Seoane J, Varela-Centelles P, Tomás I, López-Cedrún JL. Med Oral Patol Oral Cir Bucal. 2012;17:0–40. - PMC - PubMed
    1. Oral cancer diagnosis and perspectives in India. Borse V, Konwar AN, Buragohain P. http://doi: 10.1016/j.sintl.2020.100046. Sens Int. 2020;1:100046. - PMC - PubMed
    1. Incidence and mortality rates of oral cancer in California from 1995-2004. Saini RR. http://dx.doi.org/10.15406/jdhodt.2016.04.00096 J Dent Health Oral Disord Ther. 2016;4(1):10–19.
    1. Early detection of cancer. Crosby D, Bhatia S, Brindle KM, et al. Science. 2022;375:0. - PubMed
    1. Exosomes in cancer development and clinical applications. Tai YL, Chen KC, Hsieh JT, Shen TL. Cancer Sci. 2018;109:2364–2374. - PMC - PubMed

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