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Review
. 2023 Aug 15;13(8):3300-3314.
eCollection 2023.

Intracellular chloride channel 1 and tumor

Li Zhang  1 , Xingyue Chen  1 , Shun Yao  1 , Liming Zheng  1 , Xingyue Yang  1 , Yongfeng Wang  1 , Xin Li  1 , Enqin Wu  1 , Biguang Tuo  1   2
Affiliations
Review

Intracellular chloride channel 1 and tumor

Li Zhang et al. Am J Cancer Res. .

Abstract

As the major intracellular anion, chloride plays an important role in maintaining intracellular and extracellular ion homeostasis, osmotic pressure, and cell volume. Intracellular chloride channel 1, which has the physiological role of forming membrane proteins in the lipid bilayer and playing ion channels, is a hot research topic in recent years. It has been found that CLIC1 does not only act as an ion channel but also participates in cell cycle regulation, apoptosis, and intracellular oxidation; thus, it participates in the proliferation, invasion, and migration of various tumor cells in various systems throughout the body. At the same time, CLIC1 is highly expressed in tumor cells and is associated with malignancy and a poor prognosis. This paper reviews the pathological mechanisms of CLIC1 in systemic diseases, which is important for the early diagnosis, treatment, and prognosis of systemic diseases associated with CLIC1 expression.

Keywords: CLIC1; invasion; migration; proliferation; tumor.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Putative structural model of the CLIC1 protein in the soluble, reduced monomeric form. CLIC1 has an active-site cysteine residue (Cys24). The N-terminus and C-terminus of CLIC1 are both cytoplasmic. The N-terminus domain is on the right (helices h1, h2, and h3), while the all-helical C-terminus domain is on the left (helices h4-h9). CLIC1, chloride intracellular channel 1; PTM, putative transmembrane region.
Figure 2
Figure 2
CLIC1 is involved in the pathogenesis of lung, esophageal squamous, gastric, liver, colon, prostate, and other cancers. LTCC, L-type Ca2+ channel blockergai.
See this image and copyright information in PMC

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