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. 2023 Jul;15(Suppl 2):S1283-S1286.
doi: 10.4103/jpbs.jpbs_119_23. Epub 2023 Jul 11.

Comparative Evaluation of the Efficacy of Two Modes of Delivery of Diclofenac for the Management of Post-Endodontic Pain: A Randomized Controlled Clinical Trial

Munish Dheeraj  1 , Suksham Johar  2 , Priya Mahajan  3 , Tania Jandial  4 , Shikha Chauhan  5 , Kamakshi Gupta  6
Affiliations

Comparative Evaluation of the Efficacy of Two Modes of Delivery of Diclofenac for the Management of Post-Endodontic Pain: A Randomized Controlled Clinical Trial

Munish Dheeraj et al. J Pharm Bioallied Sci. 2023 Jul.

Abstract

Background: This study aimed to compare the efficacy of two modes of delivery of diclofenac for the management of post-endodontic pain.

Materials and methods: This study comprised 30 patients reporting to the department with pain in their teeth. Pain was assessed using the visual analog scale (VAS): group A (control group), group B (oral diclofenac), and group C (transdermal patch). A VAS was given to the patients in each group, and the severity of any pain was self-assessed by patients after 4 hrs, 8 hrs, 12 hrs, 24 hrs, and 48 hrs following the completion of treatment.

Results: A comparison between group oral and diclofenac transdermal patch was carried out. The pain frequency was measured at 4 hrs, 8 hrs, 12 hrs, 24 hrs, and 48 hrs postoperatively with P values of 0.744, 0.035, 0.570, 0.060, and 0.508 and was statistically insignificant.

Conclusion: Preoperative analgesics play an important role in reducing post-endodontic pain. Transdermal patches containing diclofenac show a promising analgesic modality in managing endodontic pain.

Keywords: Diclofenac; endodontic pain; transdermal drug.

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Conflict of interest statement

There are no conflicts of interest.

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