What does SARS-CoV-2 tell us about the aetiology of environmental triggers for diabetes in children and young people?

Caroline Ponmani¹, Mark D Lyttle^{2

3}, Michael Barrett^{4

5}, Tony Hulse⁶, Ruud G Nijman^{7

8}, Damian Roland^{9

10}; DIMPLES study group

Affiliations

¹ Department of Paediatric Emergency Medicine, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UK.
² Emergency Department, Bristol Royal Hospital for Children, Bristol, UK.
³ Research in Emergency Care Avon Collaborative Hub (REACH), University of the West of England, Bristol, UK.
⁴ Department of Paediatric Emergency Medicine, Children's Health Ireland, Dublin, Ireland.
⁵ Women's and Children's Health, School of Medicine, University College Dublin, Dublin, Ireland.
⁶ Department of Paediatric Endocrinology, Evelina London Children's Hospital, Guys and St.Thomas' NHS Foundation Trust, London, UK.
⁷ Division of Medicine, Department of Pediatric Emergency Medicine, St. Mary's Hospital-Imperial College NHS Healthcare Trust, London, UK.
⁸ Section of Pediatric Infectious Diseases, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, UK Centre for Pediatrics and Child Health, London, UK.
⁹ SAPPHIRE Group, Health Sciences, Leicester University, Leicester, UK.
¹⁰ Paediatric Emergency Medicine Leicester Academic (PEMLA) Group, Children's Emergency Medicine, Leicester Royal Infirmary, Leicester, UK.

Caroline Ponmani et al. Acta Paediatr. 2023 Dec.

. 2023 Dec;112(12):2462-2464.

doi: 10.1111/apa.16971. Epub 2023 Sep 11.

Caroline Ponmani¹, Mark D Lyttle^{2

3}, Michael Barrett^{4

5}, Tony Hulse⁶, Ruud G Nijman^{7

8}, Damian Roland^{9

10}; DIMPLES study group

¹ Department of Paediatric Emergency Medicine, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UK.
² Emergency Department, Bristol Royal Hospital for Children, Bristol, UK.
³ Research in Emergency Care Avon Collaborative Hub (REACH), University of the West of England, Bristol, UK.
⁴ Department of Paediatric Emergency Medicine, Children's Health Ireland, Dublin, Ireland.
⁵ Women's and Children's Health, School of Medicine, University College Dublin, Dublin, Ireland.
⁶ Department of Paediatric Endocrinology, Evelina London Children's Hospital, Guys and St.Thomas' NHS Foundation Trust, London, UK.
⁷ Division of Medicine, Department of Pediatric Emergency Medicine, St. Mary's Hospital-Imperial College NHS Healthcare Trust, London, UK.
⁸ Section of Pediatric Infectious Diseases, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, UK Centre for Pediatrics and Child Health, London, UK.
⁹ SAPPHIRE Group, Health Sciences, Leicester University, Leicester, UK.
¹⁰ Paediatric Emergency Medicine Leicester Academic (PEMLA) Group, Children's Emergency Medicine, Leicester Royal Infirmary, Leicester, UK.

No abstract available

References

1. Ponmani C, Nijman RG, Roland D, et al. Children presenting with diabetes and diabetic ketoacidosis to emergency departments during the COVID-19 pandemic in the UK and Ireland: an international retrospective observational study. Arch Dis Child. 2023. Published Online First: May 17, 2023. doi: 10.1136/archdischild-2022-32528
1. Kamrath C, Rosenbauer J, Eckert AJ, et al. Incidence of type 1 diabetes in children and adolescents during the COVID-19 pandemic in Germany: results from the DPV registry. Diabetes Care. 2022;45(8):1762-1771. doi:10.2337/dc21-0969
1. Knip M, Parviainen A, Turtinen M, et al. Finnish pediatric diabetes register. SARS-CoV-2 and type 1 diabetes in children in Finland: an observational study. Lancet Diabetes Endocrinol. 2023;11(4):251-260. doi:10.1016/S2213-8587(23)00041-4
1. Zareini B, Sørensen KK, Eiken PA, et al. Association of COVID-19 and development of type 1 diabetes: a Danish Nationwide register study. Diabetes Care. 2023;46(8):1477-1482.
1. Knip M, Simell O. Environmental triggers of type 1 diabetes. Cold Spring Harb Perspect Med. 2012;2(7):a007690. doi:10.1101/cshperspect.a007690