Polygene risk scores and randomized experiments

Lauren N Ross¹, Kenneth S Kendler², James F Woodward³

Affiliations

¹ Logic and Philosophy of Science Department, University of California-Irvine, Irvine, CA, USA rossl@uci.edu https://www.lps.uci.edu/~rossl/.
² Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA kenneth.kendler@vcuhealth.org https://vipbg.vcu.edu/people/kenneth-kendler/.
³ Department of History and Philosophy of Science, University of Pittsburgh, Pittsburgh, PA, USA jfw@pitt.edu https://jameswoodward.org.

PMID: 37694930
DOI: 10.1017/S0140525X22002151

Comment

Polygene risk scores and randomized experiments

Lauren N Ross et al. Behav Brain Sci. 2023.

. 2023 Sep 11:46:e198.

doi: 10.1017/S0140525X22002151.

Authors

Lauren N Ross¹, Kenneth S Kendler², James F Woodward³

Affiliations

¹ Logic and Philosophy of Science Department, University of California-Irvine, Irvine, CA, USA rossl@uci.edu https://www.lps.uci.edu/~rossl/.
² Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA kenneth.kendler@vcuhealth.org https://vipbg.vcu.edu/people/kenneth-kendler/.
³ Department of History and Philosophy of Science, University of Pittsburgh, Pittsburgh, PA, USA jfw@pitt.edu https://jameswoodward.org.

PMID: 37694930
DOI: 10.1017/S0140525X22002151

Abstract

We explore Madole & Harden's (2022) suggestion that single-nucleotide polymorphism (SNP)/trait correlations are analogous to randomized experiments and thus can be given a causal interpretation.

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Comment in

Causal complexity in human research: On the shared challenges of behavior genetics, medical genetics, and environmentally oriented social science.
Madole JW, Harden KP. Madole JW, et al. Behav Brain Sci. 2023 Sep 11;46:e206. doi: 10.1017/S0140525X23000833. Behav Brain Sci. 2023. PMID: 37694936

Comment on

Building causal knowledge in behavior genetics.
Madole JW, Harden KP. Madole JW, et al. Behav Brain Sci. 2022 May 5;46:e182. doi: 10.1017/S0140525X22000681. Behav Brain Sci. 2022. PMID: 35510303

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Polygene risk scores and randomized experiments

Affiliations

Polygene risk scores and randomized experiments

Authors

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Abstract

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