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Comment
. 2023 Sep 11:46:e200.
doi: 10.1017/S0140525X22002230.

Genome-wide association study and the randomized controlled trial: A false equivalence

Paul Siegel  1
Affiliations
Comment

Genome-wide association study and the randomized controlled trial: A false equivalence

Paul Siegel. Behav Brain Sci. .

Abstract

Madole & Harden's assertion that the effects derived from within-family genome-wide association studies (GWASs) and from randomized controlled trials (RCTs) are equivalent is misleading. GWASs are substantially more "non-unitary, non-uniform, and non-explanatory" than RCTs. While the within-family GWAS bring us closer to identifying genetic causes, whether it will change behavioral genetics into a causal science is an open question.

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