Social scientists would do well to steer clear of polygenic scores
- PMID: 37694985
- DOI: 10.1017/S0140525X22002448
Social scientists would do well to steer clear of polygenic scores
Abstract
The problems with polygenic scores (PGSs) have been understated. The fact that they are ancestry-specific means that biases related to sociodemographic factors would be impossible to avoid. Additionally, the requirement to obtain DNA would have profound impacts on study design and required resources, as well as likely introducing recruitment bias. PGSs are unhelpful for social science research.
Comment in
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Polygenic scores for social science: Clarification, consensus, and controversy.Behav Brain Sci. 2023 Sep 11;46:e232. doi: 10.1017/S0140525X23000845. Behav Brain Sci. 2023. PMID: 37694994 Free PMC article.
Comment on
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Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology.Behav Brain Sci. 2022 May 13;46:e207. doi: 10.1017/S0140525X22001145. Behav Brain Sci. 2022. PMID: 35551690 Free PMC article.
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