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Comment
. 2023 Sep 11:46:e227.
doi: 10.1017/S0140525X22002321.

GWASs and polygenic scores inherit all the old problems of heritability estimates

Sahotra Sarkar  1
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Comment

GWASs and polygenic scores inherit all the old problems of heritability estimates

Sahotra Sarkar. Behav Brain Sci. .

Abstract

Polygenic score (PGS) computations assume an additive model of gene action because associations between phenotypes and alleles at different loci are compounded, ignoring interactions between alleles or loci let alone between genotype and environment. Consequently, PGSs are subject to the same objections that invalidated traditional heritability analyses in the 1970s. Thus, PGSs should not be used in the social sciences.

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