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Review
. 2023 Aug-Sep;39(8-9):632-642.
doi: 10.1051/medsci/2023097. Epub 2023 Sep 11.

[Animal models of balance pathologies: New tools to study peripheral vestibulopathies]

[Article in French]
Brahim Tighilet  1 , Jessica Trico  1 , Frédéric Xavier  1 , Christian Chabbert  1
Affiliations
Free article
Review

[Animal models of balance pathologies: New tools to study peripheral vestibulopathies]

[Article in French]
Brahim Tighilet et al. Med Sci (Paris). 2023 Aug-Sep.
Free article

Abstract
in English, French

The different types of peripheral vestibulopathies (PVs) or peripheral vestibular disorders (PVDs) are essentially diagnosed on the basis of their clinical expression. The heterogeneity of vestibular symptoms makes it difficult to stratify patients for therapeutic management. Animal models of PVs are a good mean to search for clinical evaluation criteria allowing to objectively analyze the kinetics of expression of the vertigo syndrome and to evaluate the benefits of therapeutic strategies, whether they are pharmacological or rehabilitative. The question of the predictability of these animal models is therefore crucial for the identification of behavioral and biological biomarkers that could then be used in the human clinic. In this review, we propose an overview of the different animal models of PVs, and discuss their relevance for the understanding of the underlying pathophysiological mechanisms and the development of new and more targeted therapeutic approaches.

Title: Les vestibulopathies périphériques - De nouveaux modèles d’étude.

Abstract: Les vestibulopathies périphériques (VP) ou désordres vestibulaires périphériques (DVP) sont diagnostiqués surtout selon leur expression clinique, mais l’hétérogénéité des symptômes vestibulaires rend difficile la stratification des patients pour leur prise en charge thérapeutique. Les modèles animaux constituent un moyen d’identifier des critères d’évaluation clinique afin d’analyser la cinétique d’expression du syndrome vertigineux et d’évaluer les bénéfices des stratégies thérapeutiques, qu’elles soient pharmacologiques ou rééducatives. La question de la prédictibilité de ces modèles est donc cruciale pour l’identification de biomarqueurs comportementaux et biologiques qui pourraient être exploités en clinique. Dans cette revue, nous proposons un état des lieux des différents modèles animaux de VP, et discutons de leur pertinence pour la compréhension des mécanismes physiopathologiques impliqués et le développement de nouvelles approches thérapeutiques plus ciblées.

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References

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