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Review
. 2023:441:185-208.
doi: 10.1007/978-3-031-35139-6_7.

Sex-Linked Differences in Malaria Risk Across the Lifespan

Jessica Briggs  1 , Margaret Murray  1 , Jason Nideffer  2 , Prasanna Jagannathan  3
Affiliations
Review

Sex-Linked Differences in Malaria Risk Across the Lifespan

Jessica Briggs et al. Curr Top Microbiol Immunol. 2023.

Abstract

Despite the high burden of malaria worldwide, there is surprisingly scarce research on sex-based differences in malaria outside of pregnancy. A more thorough understanding of sexual dimorphism in malaria, and what underlies these sex-based differences, could elucidate the underlying mechanisms driving malaria pathogenesis and has the potential to inform malaria control efforts, including new vaccines. This review summarizes our current understanding of sex-based differences in the epidemiology of malaria across the lifespan, potential sex- or gender-based mechanisms driving these differences, and the knowledge gaps that need to be addressed.

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