Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov:167:115467.
doi: 10.1016/j.biopha.2023.115467. Epub 2023 Sep 9.

1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases

Cosima C Hoch  1 , Julie Petry  1 , Lena Griesbaum  1 , Tobias Weiser  1 , Kathrin Werner  1 , Michael Ploch  2 , Admar Verschoor  1 , Gabriele Multhoff  3 , Ali Bashiri Dezfouli  4 , Barbara Wollenberg  5
Affiliations
Free article
Review

1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases

Cosima C Hoch et al. Biomed Pharmacother. 2023 Nov.
Free article

Abstract

1,8-cineole (Eucalyptol), a naturally occurring compound derived from botanical sources such as eucalyptus, rosemary, and camphor laurel, has a long history of use in traditional medicine and exhibits an array of biological properties, including anti-inflammatory, antioxidant, antimicrobial, bronchodilatory, analgesic, and pro-apoptotic effects. Recent evidence has also indicated its potential role in managing conditions such as Alzheimer's disease, neuropathic pain, and cancer. This review spotlights the health advantages of 1,8-cineole, as demonstrated in clinical trials involving patients with respiratory disorders, including chronic obstructive pulmonary disease, asthma, bronchitis, and rhinosinusitis. In addition, we shed light on potential therapeutic applications of 1,8-cineole in various conditions, such as depression, epilepsy, peptic ulcer disease, diarrhea, cardiac-related heart diseases, and diabetes mellitus. A comprehensive understanding of 1,8-cineole's pharmacodynamics and safety aspects as well as developing effective formulations, might help to leverage its therapeutic value. This thorough review sets the stage for future research on diverse health benefits and potential uses of 1,8-cineole in tackling complex medical conditions.

Keywords: 1,8-cineole; Anti-inflammatory activity; Antimicrobial; Antioxidant; Eucalyptol; Respiratory disorders.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest Michael Ploch is employed by Cassella-med GmbH & Co. KG, located at Gereonsmühlengasse 1, 50670 Cologne, Germany. He provided guidance during the writing process, but was not involved in the design, exploration, or graphical representation of this review article. As such, any potential conflict of interest does not affect the objectivity of this review article. The other authors—Cosima C. Hoch, Julie Petry, Lena Griesbaum, Tobias Weiser, Kathrin Werner, Admar Verschoor, Gabriele Multhoff, Ali Bashiri Dezfouli, and Barbara Wollenberg—assert that this research was carried out without any conflicts of interest influencing their work.

LinkOut - more resources