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Review
. 2023 Sep 11;23(1):372.
doi: 10.1186/s12886-023-03118-6.

Research progress on the pathogenesis of diabetic retinopathy

Hongbo Li #  1 , Xinyu Liu #  2 , Hua Zhong  2 , Jiani Fang  2 , Xiaonan Li  2 , Rui Shi  3 , Qi Yu  4
Affiliations
Review

Research progress on the pathogenesis of diabetic retinopathy

Hongbo Li et al. BMC Ophthalmol. .

Abstract

Diabetic retinopathy is one of the most common and serious microvascular complications of diabetes mellitus. There are many factors leading to diabetic retinopathy, and its pathogenesis is still unclear. At present, there are still no effective measures for the early treatment of diabetic retinopathy, and the treatment options available when diabetes progresses to advanced stages are very limited, and the treatment results are often unsatisfactory. Detailed studies on the molecular mechanisms of diabetic retinopathy pathogenesis and the development of new therapeutic agents are of great importance. This review describes the potential pathogenesis of diabetic retinopathy for experimental studies and clinical practice.

Keywords: Amino acid metabolism; Diabetic retinopathy; Gene epigenetic inheritance; Hemoglobin; Inflammatory reaction; Intestinal flora; Mitochondrial disorders; Oxidative stress.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Pathways of action of relevant mechanisms in the development of DR
See this image and copyright information in PMC

References

    1. Lee R, Wong TY, Sabanayagam C. Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vision (London, England) 2015;2:17. - PMC - PubMed
    1. Tan GS, Cheung N, Simó R, Cheung GC, Wong TY. Diabetic macular oedema. Lancet Diabetes Endocrinol. 2017;5(2):143–155. - PubMed
    1. Domingueti CP, Dusse LM, Carvalho M, de Sousa LP, Gomes KB, Fernandes AP. Diabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. J Diabetes Complications. 2016;30(4):738–745. - PubMed
    1. Li C, Miao X, Li F, Wang S, Liu Q, Wang Y, Sun J. Oxidative stress-related mechanisms and antioxidant therapy in diabetic retinopathy. Oxid Med Cell Longev. 2017;2017:9702820. - PMC - PubMed
    1. Wu MY, Yiang GT, Lai TT, Li CJ. The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy. Oxid Med Cell Longev. 2018;2018:3420187. - PMC - PubMed