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. 2023 Jan-Dec:29:10760296231199732.
doi: 10.1177/10760296231199732.

Clinical Values of Coagulation Factors X, XI, and XII in Cerebral Venous Sinus Thrombosis During Perinatal State

Ming Li  1 , Shibo Duan  2 , Guowei Xu  2 , Song Li  2 , Min Sun  3 , Xiuzhen Hou  1 , Yan Jin  4
Affiliations

Clinical Values of Coagulation Factors X, XI, and XII in Cerebral Venous Sinus Thrombosis During Perinatal State

Ming Li et al. Clin Appl Thromb Hemost. 2023 Jan-Dec.

Abstract

Cerebral venous sinus thrombosis (CVST) has become a rare but potentially life-threatening condition in perinatal women. Early and rapid identification of CVST in pregnant women is a challenge for frontline clinical workers. In this study, 40 perinatal patients with CVST in our hospital were included in the five-year period, and 120 normal perinatal pregnant women in the obstetrics and gynecology department of our hospital were randomly enrolled in the five-year period as the control group, including 60 cases in pregnancy and puerperium. 5 mL of fasting venous blood was collected from puerperal CVST patients in the acute phase of onset (within 72 h of onset) and the recovery phase (fourth week of treatment). In the control group, 5 mL of fasting venous blood was collected. Coagulation factors X, XI, and XII, plasma D-Dimer were analyzed and compared. Coagulation factors X, XI, and XII in plasma of CVST patients were significantly increased compared with controls. Plasma coagulation factors X, XI, and XII and their combined detection (Union Model = 0.056 * FX: C + 0.046 * FXI: C + 0.081 * FXII: C) have diagnostic values for perinatal CVST. Plasma coagulation factors X, XI, and XII were significantly positively correlated with plasma D-dimer levels in perinatal CVST patients. Plasma coagulation factors X, XI, and XII have diagnostic values for perinatal CVST.

Keywords: cerebral venous sinus thrombosis; coagulation factor; diagnosis; perinatal state.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Comparisons of plasma coagulation factors X (A), XI (B), and XII (C) between women with cerebral venous sinus thrombosis (CVST, n = 40) and normal controls (control, n = 120) during perinatal state. Data were shown with mean ± SD. ***P < .001 from unpaired t test with Welch's correction.
Figure 2.
Figure 2.
Receiver operating characteristic (ROC) analysis of diagnostic values of plasma coagulation factors X, XI, XII, and their combination test for cerebral venous sinus thrombosis during perinatal state.
Figure 3.
Figure 3.
Pearson correlation analysis of plasma D-Dimer with coagulation factors X (A), XI (B), and XII (C) in women with cerebral venous sinus thrombosis (CVST, n = 40) during perinatal state.
Figure 4.
Figure 4.
Changes of plasma coagulation factors X (A), XI (B), and XII (C) in women with cerebral venous sinus thrombosis (CVST, n = 40) during perinatal state at the time of acute stage and recovery stage. ***P < .001 from paired t test.
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