Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Nov;45(11):2780-2788.
doi: 10.1002/hed.27497. Epub 2023 Sep 12.

Evaluating depth of invasion across oral cavity subsites as part of the AJCC 8th edition T staging criteria for oral cavity squamous cell carcinoma

Shivee Gilja  1 , Joshua Barlow  1 , Arvind Kumar  1 , Michael H Berger  1 , Mohemmed N Khan  1 , Diana N Kirke  1 , Scott A Roof  1
Affiliations

Evaluating depth of invasion across oral cavity subsites as part of the AJCC 8th edition T staging criteria for oral cavity squamous cell carcinoma

Shivee Gilja et al. Head Neck. 2023 Nov.

Abstract

Background: The prognostic impact of depth of invasion (DOI) in American Joint Committee on Cancer 8th edition TNM staging for oral cavity squamous cell carcinoma (OCSCCa) across oral cavity subsites is unknown.

Methods: Overall survival of patients with pT1-4a OCSCCa in the National Cancer Database (2010-2017), stratified by tumor size and DOI across eight oral cavity subsites, was evaluated using multivariable-adjusted Cox proportional hazards modeling.

Results: When stratified by tumor size ≤2 cm and >2 cm, DOI >5 mm and DOI >10 mm were only associated with worse overall survival, respectively, for tumors of the oral tongue (Tumor size ≤2 cm, DOI >5 mm v DOI ≤5 mm: HR: 1.31, 95% CI: 1.12-1.53, p < 0.001; Tumor size >2 cm, DOI >10 mm v DOI ≤10 mm: HR: 1.15, 95% CI: 1.01-1.30, p = 0.03). DOI >5 mm and DOI >10 mm was not prognostic for any other tumor location.

Conclusions: These findings suggest that the current staging schema for DOI in OCSCCa may not be prognostic across all oral cavity subsites.

Keywords: T staging; depth of invasion; oral cavity squamous cell carcinoma; oral cavity subsites; tumor size.

PubMed Disclaimer

References

REFERENCES

    1. Amin MB. AJCC Cancer Staging Manual. Eighth Ed. Cancer Staging Manual. Springer International Publishing; 2017.
    1. Edge SB, Byrd DR, Carducci MA, Compton CC, Fritz A, Greene F. AJCC Cancer Staging Manual. Vol 7. Springer; 2010.
    1. Lydiatt WM, Patel SG, O'Sullivan B, et al. Head and Neck cancers-major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(2):122-137. doi:10.3322/caac.21389
    1. Matos LL, Dedivitis RA, Kulcsar MAV, de Mello ES, Alves VAF, Cernea CR. External validation of the AJCC Cancer Staging Manual, 8th edition, in an independent cohort of oral cancer patients. Oral Oncol. 2017;71:47-53. doi:10.1016/j.oraloncology.2017.05.020
    1. Tirelli G, Gatto A, Boscolo Nata F, et al. Prognosis of oral cancer: a comparison of the staging systems given in the 7th and 8th editions of the American Joint Committee on Cancer staging manual. Br J Oral Maxillofac Surg. 2018;56(1):8-13. doi:10.1016/j.bjoms.2017.11.009

MeSH terms

LinkOut - more resources