Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb;83(2):442-448.
doi: 10.1007/s12020-023-03496-3. Epub 2023 Sep 12.

Impact of the number of intermediate risk factors on outcome of papillary thyroid cancer

Murilo Oliveira Cerci  1 , Lígia Vera Montali de Assumpção  1 , Denise Engelbrecht Zantut-Wittmann  2
Affiliations

Impact of the number of intermediate risk factors on outcome of papillary thyroid cancer

Murilo Oliveira Cerci et al. Endocrine. 2024 Feb.

Abstract

Purpose: The 2015 American Thyroid Association risk stratification system (2015-RSS) is used to assess the tumor recurrence rate and guide the initial treatment. At the current moment, patients with one or multiple intermediate risk factors (IRF) have the same treatment. This study was conducted to evaluate the impact of the number of IRF characteristics on tumor persistence or recurrence rates.

Methods: Patients with intermediate risk papillary thyroid cancer (PTC) were selected and analyzed, furthermore, they were divided into two subgroups, one with 1-2 IRF and another with ≥3 IRF. Those data were analyzed in relation to response to therapy at the end of the first year and in last appointment, time to reach non evidence of disease (NED) state and time in NED state.

Results: A total of 257 patients were evaluated. Extrathyroidal invasion, vascular invasion, the total number of IRF and the subgroup of ≥3 IRF were associated with non-excellent response in last consultation; IRF lymph node metastasis was associated with non-excellent response in the first year and in last appointment and prolonged time in NED state; vascular invasion was associated with a shorter time in NED state; total number of IRF and aggressive histology were related to delay in the achievement of NED state.

Conclusions: Higher number of IRF was a predictive factor of non-excellent response in the last visit and was associated with longer time to reach the NED state. Those data suggest a benefit from closer follow-up and more intensive treatment in these patients.

Keywords: Intermediate risk; Papillary thyroid cancer; Risk factors; Thyroid cancer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. H. Lim, S.S. Devesa, J.A. Sosa, D. Check, C.M. Kitahara, Trends in thyroid cancer incidence and mortality in the United States, 1974-2013. JAMA 317, 1338–1348 (2017). https://doi.org/10.1001/jama.2017.2719 - DOI - PubMed - PMC
    1. M.K. Cari, B.S. Arthur, Epidemiology of thyroid cancer. Cancer Epidemiol. Biomark. Prev. 31, 1284–1297 (2022). https://doi.org/10.1158/1055-9965.EPI-21-1440 - DOI
    1. Z.W. Baloch, S.L. Asa, J.A. Barletta, R.A. Ghossein, C.C. Juhlin, C.K. Jung, V.A. LiVolsi, M.G. Papotti, M. Sobrinho-Simões, G. Tallini, O. Mete, Overview of the 2022 WHO classification of thyroid neoplasms. Endocr. Pathol. 33, 27–63 (2022). https://doi.org/10.1007/s12022-022-09707-3 - DOI - PubMed
    1. R.M. Tuttle, B. Haugen, N.D. Perrier, Updated American Joint Committee on cancer/tumor-node-metastasis staging system for differentiated and anaplastic thyroid cancer (eighth edition): what changed and why? Thyroid 27, 751–756 (2017). https://doi.org/10.1089/thy.2017.0102 - DOI - PubMed - PMC
    1. B.R. Haugen, E.K. Alexander, K.C. Bible, G.M. Doherty, S.J. Mandel, Y.E. Nikiforov, F. Pacini, G.W. Randolph, A.M. Sawka, M. Schlumberger, K.G. Schuff, S.I. Sherman, J.A. Sosa, D.L. Steward, R.M. Tuttle, L. Wartofsky, 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26, 1–133 (2016). https://doi.org/10.1089/thy.2015.0020 - DOI - PubMed - PMC

LinkOut - more resources