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Comment
. 2023 Nov 14;29(22):4521-4523.
doi: 10.1158/1078-0432.CCR-23-1953.

Rerouting the GPS Directing Immunotherapy in Endometrial Cancer

Rhea Jangra  1 , Neesha C Dhani  1
Affiliations
Comment

Rerouting the GPS Directing Immunotherapy in Endometrial Cancer

Rhea Jangra et al. Clin Cancer Res. .

Abstract

Mismatch repair (MMR) status alone is insufficient to guide the use of PD-(L)1 monotherapy in patients with endometrial cancer. Additional biomarkers, including tumor mutational burden and combined positive score, may help to identify patients with MMR-proficient tumors with a high probability of benefit from PD-(L)1 monotherapy, and those with MMR-deficient tumors who might require combination strategies. See related article by Oaknin et al., p. 4564.

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