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Comment
. 2023 Sep 11;58(17):1515-1516.
doi: 10.1016/j.devcel.2023.08.020.

KRASG12D inhibition in pancreatic cancer: Fas expression facilitates immune clearance

Celine Yeh  1 , Wungki Park  2 , Rona Yaeger  3
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KRASG12D inhibition in pancreatic cancer: Fas expression facilitates immune clearance

Celine Yeh et al. Dev Cell. .
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Abstract

In an article in this issue of Developmental Cell and in a second paper in Cancer Cell, Mahadevan et al. demonstrate that KrasG12D suppression remodels the immunosuppressive microenvironment of KrasG12D pancreatic cancers, recruits activated CD8+ cytotoxic T cells, and epigenetically upregulates Fas expression in cancer cells, leading to tumor clearance via Fas/FasL-mediated apoptosis.

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Conflict of interest statement

Declaration of interests C.Y. declares no competing interests. W.P. is a consultant for Astellas, EXACT Therapeutics AS, American Physician Institute, Curio Science, TEMPUS, and Integrity Continuing Education and receives research funding to his institution from Merck, Astellas, and Miracogen. R.Y. is a consultant for Mirati Therapeutics and Amgen (unpaid), has received speaker’s honorarium from Zai Lab, and receives research funding to her institution from Mirati Therapeutics, Pfizer, Boehringer Ingelheim, and Daiichi Sankyo.

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