Colonic motility and enema spreading
- PMID: 3769964
- DOI: 10.1007/BF00256916
Colonic motility and enema spreading
Abstract
Radiolabelled enema solution was administered to eight healthy subjects, both in fasted and fed states. Enema spreading was monitored over a 4-h period using gamma scintigraphy and colonic motility was recorded simultaneously using a pressure sensitive radiotelemetry capsule. The rate and extent of enema dispersion were unaffected by eating. Spreading could be correlated with colonic motility and was inhibited by aboral propulsion of the colonic contents.
Similar articles
-
Non-invasive measurement of pan-colonic pressure over a whole digestive cycle: clinical applications of a capsule-style manometric system.World J Gastroenterol. 2006 Dec 21;12(47):7690-4. doi: 10.3748/wjg.v12.i47.7690. World J Gastroenterol. 2006. PMID: 17171801 Free PMC article. Clinical Trial.
-
Proximal colonic response and gastrointestinal transit after high and low fat meals.Dig Dis Sci. 1993 Oct;38(10):1793-800. doi: 10.1007/BF01296101. Dig Dis Sci. 1993. PMID: 8404399
-
Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity.Gut. 1970 Feb;11(2):91-9. doi: 10.1136/gut.11.2.91. Gut. 1970. PMID: 5441889 Free PMC article.
-
Intraluminal pressures during perfusion of the human colon in situ.Gastroenterology. 1976 Mar;70(3):336-40. Gastroenterology. 1976. PMID: 765185 Review.
-
The transit of dosage forms through the colon.Int J Pharm. 2010 Aug 16;395(1-2):17-25. doi: 10.1016/j.ijpharm.2010.04.044. Epub 2010 Jun 1. Int J Pharm. 2010. PMID: 20576492 Review.
Cited by
-
Spread and distribution of 5-ASA colonic foam and 5-ASA enema in patients with ulcerative colitis.Dig Dis Sci. 1992 Dec;37(12):1890-7. doi: 10.1007/BF01308084. Dig Dis Sci. 1992. PMID: 1473437 Clinical Trial.
-
Pharmacokinetics of rectal drug administration, Part II. Clinical applications of peripherally acting drugs, and conclusions.Clin Pharmacokinet. 1991 Aug;21(2):110-28. doi: 10.2165/00003088-199121020-00003. Clin Pharmacokinet. 1991. PMID: 1884566 Review.