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Meta-Analysis
. 2023 Nov;33(11):3527-3538.
doi: 10.1007/s11695-023-06778-x. Epub 2023 Sep 13.

Medium-Term Weight Loss and Remission of Comorbidities Following Endoscopic Sleeve Gastroplasty: a Systematic Review and Meta-analysis

Matyas Fehervari  1   2   3 , Michael G Fadel  4 , Laith Omar Khalaf Alghazawi  4 , Bibek Das  4 , María Rita Rodríguez-Luna  5   6 , Silvana Perretta  7   5   8 , Andrew Wan  9 , Hutan Ashrafian  4
Affiliations
Meta-Analysis

Medium-Term Weight Loss and Remission of Comorbidities Following Endoscopic Sleeve Gastroplasty: a Systematic Review and Meta-analysis

Matyas Fehervari et al. Obes Surg. 2023 Nov.

Abstract

This systematic review and meta-analysis aimed to determine the short- and medium-term weight loss outcomes and comorbidity resolution following endoscopic sleeve gastroplasty. Our search identified 35 relevant studies containing data from 7525 patients. Overall, pooled short-term (12 months) total weight loss (TWL) was 16.2% (95% CI 13.1-19.4%) in 23 studies (n = 5659). Pooled medium-term TWL was 15.4% (95% CI 13.7-17.2%) in 10 studies (n = 4040). Diabetes resolution was 55.4% (95% CI 46-64%), hypertension resolution was 62.8% (95% CI 43-82%), dyslipidaemia resolution was 56.3% (95% CI 49-63%), and obstructive sleep apnoea resolution was 51.7% (95% CI 16.2-87.3%) in four studies (n = 480). This pooled analysis demonstrates that ESG can induce durable weight loss and resolution of obesity-associated comorbidities in patients with moderate obesity.

Keywords: Comorbidities; Endoscopic sleeve gastroplasty; Obesity; Weight loss.

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Conflict of interest statement

HA is a Chief Scientific Officer of Preemptive Health and Medicine, Flagship Pioneering. All other authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Flow diagram: process for selection of studies. Adapted from PRISMA 2009 flow diagram [13]
Fig. 2
Fig. 2
Forest plot of A %TWL and B %EWL 12 months after ESG
Fig. 3
Fig. 3
Forest plot of A %TWL and B %EWL over medium term (2–5 years) following ESG
Fig. 4
Fig. 4
Forest plot of A diabetes mellitus remission and B reduction of HbA1c reduction 12 months after ESG
Fig. 5
Fig. 5
Forest plot of remission of hypertension following ESG
Fig. 6
Fig. 6
Forest plot of A resolution of dyslipidaemia, B change in triglyceride, and C low-density lipoprotein following ESG
Fig. 7
Fig. 7
Forest plot of resolution of obstructive sleep apnoea following ESG
See this image and copyright information in PMC

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