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. 2023 Sep 12;190(10):388.
doi: 10.1007/s00604-023-05969-8.

Ti3C2Tx-rGO-chitosan-based microcatheter sensor for real-time continuous monitoring of propofol: toward improved anesthetic management

Chandan Kafley  1 , Rahul P K  1 , Shekher Kummari  1 , Kavitha Lakavath  1 , Yugender Goud Kotagiri  2
Affiliations

Ti3C2Tx-rGO-chitosan-based microcatheter sensor for real-time continuous monitoring of propofol: toward improved anesthetic management

Chandan Kafley et al. Mikrochim Acta. .

Abstract

We are aiming to develop an electrochemical microcatheter sensor for the detection and real-time continuous monitoring of propofol (PPF), which is an anesthetic drug majorly used during medical treatment. This proposed microcatheter-based sensing strategy meets the challenge of real-time periodic and continuous monitoring of propofol by using d-Ti3C2Tx-rGO-chi-modified carbon paste microcatheter sensor transducer. The sensing methodology relies on voltammetry and chronoamperometry transduction methods. The reusable microcatheter sensor was fabricated by embedding the three electrodes into a few millimeters-wide Teflon tube. The nanocomposite was characterized using advanced analytical instruments such as XRD, FE-SEM, EDX, Raman spectroscopy, and XPS. Further, electrode interfacial properties were characterized with voltammetry and electrochemical impedance spectroscopy. The electroanalytical performance of the modified microcatheter sensor was tested for the detection of PPF in phosphate buffer by using chronoamperometry with a wide linear range of 5 to 110 µM (at an applied potential of 0.3 V vs. Ag/AgCl). The sensor's practical potency was confirmed in human serum with a dynamic linear range of 10 to 130 µM. The sensor exhibited a good limit of detection values in phosphate buffer (2 µM) and natural human plasma (4 µM). The new sensor displays different dimensions of information while displaying high sensitivity, selectivity, and long-term stability. The outstanding analytical performance of the developed sensor holds considerable promise for the continuous monitoring of propofol, its effective management, and optimization of the doses in the patient's body.

Keywords: Anesthetic management; Chitosan; Chronoamperometry; Microcatheter electrode; Reduced graphene oxide; Ti3C2Tx; Voltammetry.

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References

    1. Sahinovic MM, Struys MMRF, Absalom AR (2018) Clinical pharmacokinetics and pharmacodynamics of propofol. Clin Pharmacokinet 57:1539–1558. https://doi.org/10.1007/s40262-018-0672-3 - DOI - PubMed - PMC
    1. Arjun AM, Krishna PH, Nath AR, Rasheed PA (2022) A review on advances in the development of electrochemical sensors for the detection of anesthetic drugs. Anal Methods 14:4040–4052. https://doi.org/10.1039/D2AY01290A - DOI - PubMed
    1. Kivlehan F, Garay F, Guo J et al (2012) Toward Feedback-controlled anesthesia: voltammetric measurement of propofol (2,6-diisopropylphenol) in serum-like electrolyte solutions. Anal Chem 84:7670–7676. https://doi.org/10.1021/ac3006878 - DOI - PubMed
    1. Obara S, Noji Y, Hasegawa T et al (2019) A patient with intraoperative awareness history requiring high propofol effect-site concentrations for general anesthesia. JA Clin Reports 5:71. https://doi.org/10.1186/s40981-019-0290-6 - DOI
    1. Stradolini F, Kilic T, Di Consiglio A et al (2018) Long-term monitoring of propofol and fouling effect on pencil graphite electrodes. Electroanalysis 30:1363–1369. https://doi.org/10.1002/elan.201700834 - DOI

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