Pharmacokinetics of albendazole in man
- PMID: 3770064
- DOI: 10.1007/BF00608219
Pharmacokinetics of albendazole in man
Abstract
The pharmacokinetics of albendazole were investigated in healthy volunteers and in patients receiving albendazole for treatment of hydatid disease. Unchanged albendazole was below detectable limits in plasma, urine, bile and cyst fluid. The major metabolite present in all fluids was the sulfoxide. Maximum concentrations of albendazole sulfoxide in plasma were very variable, probably due to variable absorption of albendazole.
Similar articles
-
Penetration of albendazole sulphoxide into hydatid cysts.Gut. 1987 Jan;28(1):75-80. doi: 10.1136/gut.28.1.75. Gut. 1987. PMID: 3817589 Free PMC article.
-
[Study of the distribution of albendazole sulfoxide by liquid chromatography in plasma and cyst fluid in hydatidosis].Ann Pharm Fr. 1988;46(1):15-8. Ann Pharm Fr. 1988. PMID: 3218831 French. No abstract available.
-
Albendazole--objective evidence of response in human hydatid disease.JAMA. 1985 Apr 12;253(14):2053-7. doi: 10.1001/jama.253.14.2053. JAMA. 1985. PMID: 3883020
-
Albendazole: a new concept in the control of intestinal helminthiasis.Gastroenterol Clin Biol. 1984 Jun-Jul;8(6-7):569-76. Gastroenterol Clin Biol. 1984. PMID: 6378710 Review. No abstract available.
-
Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus?Expert Rev Anti Infect Ther. 2009 Mar;7(2):145-9. doi: 10.1586/14787210.7.2.145. Expert Rev Anti Infect Ther. 2009. PMID: 19254162 Review. No abstract available.
Cited by
-
Isolation and identification of Paenibacillus sp. FM-6, involved in the biotransformation of albendazole.World J Microbiol Biotechnol. 2014 Oct;30(10):2747-54. doi: 10.1007/s11274-014-1698-9. Epub 2014 Jul 9. World J Microbiol Biotechnol. 2014. PMID: 25005007
-
Impairment of the ubiquitin-proteasome pathway by methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate leads to a potent cytotoxic effect in tumor cells: a novel antiproliferative agent with a potential therapeutic implication.J Biol Chem. 2012 Aug 31;287(36):30625-40. doi: 10.1074/jbc.M111.324228. Epub 2012 Jun 28. J Biol Chem. 2012. PMID: 22745125 Free PMC article.
-
Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data.Parasitol Res. 2016 Aug;115(8):2995-3001. doi: 10.1007/s00436-016-5054-x. Epub 2016 Apr 16. Parasitol Res. 2016. PMID: 27085708 Free PMC article.
-
In vitro model to assess effect of antimicrobial agents on Encephalitozoon cuniculi.Antimicrob Agents Chemother. 1994 Oct;38(10):2440-8. doi: 10.1128/AAC.38.10.2440. Antimicrob Agents Chemother. 1994. PMID: 7840584 Free PMC article.
-
Acyclic Cucurbit[n]uril-Type Molecular Container Enables Systemic Delivery of Effective Doses of Albendazole for Treatment of SK-OV-3 Xenograft Tumors.Mol Pharm. 2016 Mar 7;13(3):809-18. doi: 10.1021/acs.molpharmaceut.5b00723. Epub 2016 Jan 22. Mol Pharm. 2016. PMID: 26756920 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources