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. 1979 Jan 10;168(2):185-95.
doi: 10.1007/BF00431444.

Control of the initiation of DNA replication in Escherichia coli. I. Negative control of initiation

R Tippe-Schindler, G Zahn, W Messer

Control of the initiation of DNA replication in Escherichia coli. I. Negative control of initiation

R Tippe-Schindler et al. Mol Gen Genet. .

Abstract

A transient stimulation of the initiation of DNA replication during inhibition of protein synthesis has been demonstrated in dnaA5 and dnaA46 mutants. This suggests the existence of a negatively acting control protein (not the dnaA product) which decays rapidly or is removed during a block in protein synthesis. The stimulation of initiation is dependent on a previous accumulation of initiation specific proteins, which suggests that in addition to the negative control other control mechanisms are effective.

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