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Review
. 2023 Sep 1;31(3):283-289.
doi: 10.53854/liim-3103-3. eCollection 2023.

Clinical pharmacology of the SingleTablet Regimen (STR) Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF)

Giovanni Di Perri  1
Affiliations
Review

Clinical pharmacology of the SingleTablet Regimen (STR) Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF)

Giovanni Di Perri. Infez Med. .

Abstract

In Italy a proportion of HIV patients exceeding 50% are diagnosed at advanced stages of disease. A sizeable proportion of patients under chronic HIV treatment has a story of poor adherence with archived resistance associated mutations, a condition implying some risks in case of treatment with dual regimens. Conventional three-drug regimens will remain necessary in the short-mid term, in order to avoid treatment failure and selection of drug resistance. Efficacy, tolerability, safety, genetic barrier, forgiveness and a good compatibility with concurrent medications are all features that describe the overall quality of BIC/FTC/TAF, a combination whose robustness will remain a point of reference for the next years.

Keywords: Bictegravir; Emtricitabine; Tenofovir; single tablet regimen.

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Conflict of interest statement

Conflict of interest None to declare.

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