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. 2023 Jun 6:20:19.
doi: 10.18502/fid.v20i19.12867. eCollection 2023.

Application of Hyaluronic Acid for Treatment of Interdental Papillary Deficiency: A Systematic Review and Meta-Analysis

Jowel Makdisi  1 , Solmaz Akbari  1   2 , Farid Zayeri  3 , Hoori AslRoosta  1 , Siamak Yaghobee  1
Affiliations

Application of Hyaluronic Acid for Treatment of Interdental Papillary Deficiency: A Systematic Review and Meta-Analysis

Jowel Makdisi et al. Front Dent. .

Abstract

Objectives: The focused question of this systematic review was "does hyaluronic acid (HA) injection in areas of interdental papillary deficiency reduce black triangles?" Materials and Methods: A systematic literature search was performed to find clinical studies on human patients with a minimum of 6-month follow-up, published in English from 2005 to May 2020. There were two outcome variables: black triangle area (BTA) change after treatment at different measurement time points compared with baseline, and patient reported outcome measures (PROMs), when available. Results: Of eight eligible articles (2 randomized clinical trials (RCTs) and 6 non-randomized, non-placebo controlled clinical studies), seven reported that HA injections had a positive impact on reduction of BTA and subsequent papillary augmentation. Six studies were included in meta-analysis and showed that the intervention led to a pooled reduction percentage of 57.7% in BTA after 6 months. Although there were clinical diversities between the studies, all the studies applied the same concentration of HA (approximately 2%), 2-3 mm apical to the papilla tip in several intervals. Some degrees of relapse were reported in some studies. Conclusion: Within the limits of this study, this systematic review and meta-analysis showed that HA injection can serve as an efficient minimally-invasive treatment for small interdental papillary deficiencies. It is essential to conduct further randomized clinical studies with prolonged follow-ups in order to support this conclusion.

Keywords: Dental; Dental Papilla; Gingiva, Esthetics; Gingival Recession; Hyaluronic Acid.

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Conflict of interest statement

None declared.

Figures

Fig. 1
Fig. 1
Flowchart diagram of the search strategy, outlining the number of articles identified, screened, found eligible, and included in the systematic review
Fig. 2
Fig. 2
Egger's publication bias plot
Fig. 3
Fig. 3
Quality assessment of potential risk of bias of included RCTs based on Cochrane risk assessment tool (green: low risk; yellow: unclear risk; red: high risk)
Fig. 4
Fig. 4
Forrest plot of the pooled BTA percent change
See this image and copyright information in PMC

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