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Review
. 2023 Nov;25(11):1227-1235.
doi: 10.1007/s11912-023-01449-7. Epub 2023 Sep 13.

Chemotherapy-Induced Peripheral Neuropathy: Diagnosis, Agents, General Clinical Presentation, and Treatments

Diana Molinares  1 , Sara Kurtevski  2 , Yingrong Zhu  2
Affiliations
Review

Chemotherapy-Induced Peripheral Neuropathy: Diagnosis, Agents, General Clinical Presentation, and Treatments

Diana Molinares et al. Curr Oncol Rep. 2023 Nov.

Abstract

Purpose of review: This review aims to discuss pathophysiology, diagnosis, clinical presentation, and treatment of chemotherapy-induced peripheral neuropathy. Agent-specific presentation and pathophysiology is also being discussed.

Recent findings: As new systemic oncological treatments continue to be developed, the number of cancer survivors continues to grow. Survivors are living longer with the long-term side effects of oncological treatments. We reviewed the pathophysiology of agent-specific chemotherapy-induced peripheral neuropathy and the updates in its treatment and preventative tools. Chemotherapy-induced peripheral neuropathy is a debilitating long-term side effect that often impairs cancer survivors' function and quality of life. The increasing life expectancy of cancer survivors has resulted in increased prevalence of this condition. Understanding its intricacies can provide physicians with better treatment tools and research opportunities to develop or identify new therapeutic agents.

Keywords: CIPN; Cancer rehabilitation; Chemotherapy; Neuropathy; Survivorship.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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