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Comment
. 2023 Sep 13;21(9):e3002297.
doi: 10.1371/journal.pbio.3002297. eCollection 2023 Sep.

Wounding the stroma: Docetaxel's role in dormant breast cancer escape

Tyler T Cooper  1 , Lynne-Marie Postovit  1
Affiliations
Comment

Wounding the stroma: Docetaxel's role in dormant breast cancer escape

Tyler T Cooper et al. PLoS Biol. .

Abstract

The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. A new study in PLOS Biology reveals that docetaxel-induced injury of tumour stromal cells stimulates the release of cytokines that support dormancy escape of breast cancer cells.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Docetaxel modulates the secretome of breast cancer-associated stromal cells that “awakens” dormant tumour cells and promotes an immunosuppressive microenvironment.
See this image and copyright information in PMC

Comment on

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