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Editorial
. 2023 Nov 15;208(10):1019-1021.
doi: 10.1164/rccm.202309-1599ED.

Investigating a Causal Role for Lung Microbiome Dysbiosis in Early Chronic Obstructive Pulmonary Disease Pathogenesis

Alexa A Pragman  1
Affiliations
Editorial

Investigating a Causal Role for Lung Microbiome Dysbiosis in Early Chronic Obstructive Pulmonary Disease Pathogenesis

Alexa A Pragman. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Preclinical murine model of tobacco smoke and aspiration of oral taxa. Over a 12-week period, Sulaiman and colleagues exposed mice to tobacco smoke, aspiration of oral taxa (Streptococcus mitis, Veillonella parvula, and Prevotella melaninogenica), or the combination of tobacco smoke and aspirated oral taxa. Lung histology and immunologic responses were assessed, and the results are summarized above. Responses to tobacco smoke exposure (alone) and aspiration (alone) are illustrated in comparison with the authors’ phosphate-buffered saline negative control. Response to the combination of tobacco smoke exposure and aspiration is illustrated in comparison with aspiration alone. Illustration by Shane W. Hodgson. KC = keratinocyte-derived chemokine; LIF = leukemia inhibitory factor; Th17 = T-helper cell type 17.
See this image and copyright information in PMC

Comment on

  • Lower Airway Dysbiosis Augments Lung Inflammatory Injury in Mild-to-Moderate Chronic Obstructive Pulmonary Disease.
    Sulaiman I, Wu BG, Chung M, Isaacs B, Tsay JJ, Holub M, Barnett CR, Kwok B, Kugler MC, Natalini JG, Singh S, Li Y, Schluger R, Carpenito J, Collazo D, Perez L, Kyeremateng Y, Chang M, Campbell CD, Hansbro PM, Oppenheimer BW, Berger KI, Goldring RM, Koralov SB, Weiden MD, Xiao R, D'Armiento J, Clemente JC, Ghedin E, Segal LN. Sulaiman I, et al. Am J Respir Crit Care Med. 2023 Nov 15;208(10):1101-1114. doi: 10.1164/rccm.202210-1865OC. Am J Respir Crit Care Med. 2023. PMID: 37677136 Free PMC article.

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