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. 2023 Nov 1;48(11):956-957.
doi: 10.1097/RLU.0000000000004848. Epub 2023 Sep 7.

Anti-LGI1 Autoimmune Epilepsy

Brian J Burkett  1 , Derek R Johnson, Christopher H Hunt, Steven A Messina, Stephen M Broski
Affiliations

Anti-LGI1 Autoimmune Epilepsy

Brian J Burkett et al. Clin Nucl Med. .

Abstract

Leucine-rich glioma inactivated 1 autoimmune encephalitis is a treatable cause of autoimmune epilepsy associated with faciobrachial dystonic seizures-a rare form of epilepsy with frequent brief seizures primarily affecting the arm and face. We report a case with characteristic imaging findings. 18 F-FDG PET/CT demonstrated severe hypometabolism in the left basal ganglia, a regional abnormality associated with leucine-rich glioma inactivated 1 encephalitis.

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Conflict of interest statement

Conflicts of interest and sources of funding: none declared.

References

    1. Liu X, Shan W, Zhao X, et al. The clinical value of (18) F-FDG-PET in autoimmune encephalitis associated with LGI1 antibody. Front Neurol . 2020;11:418.
    1. Park S, Choi H, Cheon GJ, et al. 18 F-FDG PET/CT in anti-LGI1 encephalitis: initial and follow-up findings. Clin Nucl Med . 2015;40:156–158.
    1. Probasco JC, Solnes L, Nalluri A, et al. Abnormal brain metabolism on FDG-PET/CT is a common early finding in autoimmune encephalitis. Neurol Neuroimmunol Neuroinflamm . 2017;4:e352.
    1. Seniaray N, Verma R, Ranjan R, et al. Metabolic imaging patterns on 18 F-FDG PET in acute and subacute LGI1 autoimmune limbic encephalitis. Clin Nucl Med . 2021;46:e27–e28.
    1. Doroudinia A, Safarpour Lima B, Bakhshayesh Karam M, et al. Interesting manifestation of autoimmune encephalitis on FDG PET scan. Clin Nucl Med . 2022;47:e190–e191.

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