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Comment
. 2023 Sep 12;56(9):1975-1977.
doi: 10.1016/j.immuni.2023.08.017.

A universe of second messengers for cGLR-STING signaling

Xubiao Wei  1 , Conggang Zhang  2
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A universe of second messengers for cGLR-STING signaling

Xubiao Wei et al. Immunity. .
Free article

Abstract

2'3'-cyclic GMP-AMP (2'3'-cGAMP) and 3'2'-cGAMP activate STING-dependent antiviral immunity in Drosophila melanogaster but fail to control infection by C virus in some fly species. In this issue of Immunity, Cai et al. reveal that Drosophila produces multiple cyclic di-nucleotides (CDNs) in response to viral infection. One of these CDNs-2'3'-c-di-GMP-is a very potent STING activator capable of promoting antiviral immunity in otherwise susceptible flies.

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Declaration of interests The authors declare no competing interests.

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