Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Sep 12;56(9):1985-1987.
doi: 10.1016/j.immuni.2023.08.012.

Plaque attack by microglial PLCγ2

Ashley L Comer  1 , Timothy R Hammond  2
Affiliations
Free article
Comment

Plaque attack by microglial PLCγ2

Ashley L Comer et al. Immunity. .
Free article

Abstract

PLCγ2 is genetically linked to Alzheimer's disease (AD), but it is unclear how PLCγ2 contributes to pathology. Tsai et al. demonstrate that AD-associated PLCG2 variants bidirectionally orchestrate microglial responses to plaques and impact neural function in an AD mouse model. This positions PLCγ2 as a key microglial signaling node and shows that targeting PLCγ2 could have therapeutic benefits in AD.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests A.L.C. and T.R.H. are employees of Sanofi.

Comment on

Substances

LinkOut - more resources