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Comment
. 2023 Sep 12;56(9):1988-1990.
doi: 10.1016/j.immuni.2023.08.010.

Making good of a tricky start: How IgE and mast cells manage a protective sway in food allergy

Mariana C G Miranda-Waldetario  1 , Maria A Curotto de Lafaille  2
Affiliations
Free article
Comment

Making good of a tricky start: How IgE and mast cells manage a protective sway in food allergy

Mariana C G Miranda-Waldetario et al. Immunity. .
Free article

Abstract

The immune and nervous systems respond to dangerous stimuli to maintain homeostasis. In a recent issue of Nature, Florsheim et al. and Plum et al. uncover the crosstalk between immunoglobulin E (IgE)-mast-cell-mediated immune activation and neural responses driving behavioral avoidance of allergenic food.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Immune sensing of food allergens promotes avoidance behaviour.
    Florsheim EB, Bachtel ND, Cullen JL, Lima BGC, Godazgar M, Carvalho F, Chatain CP, Zimmer MR, Zhang C, Gautier G, Launay P, Wang A, Dietrich MO, Medzhitov R. Florsheim EB, et al. Nature. 2023 Aug;620(7974):643-650. doi: 10.1038/s41586-023-06362-4. Epub 2023 Jul 12. Nature. 2023. PMID: 37437602 Free PMC article.
  • Mast cells link immune sensing to antigen-avoidance behaviour.
    Plum T, Binzberger R, Thiele R, Shang F, Postrach D, Fung C, Fortea M, Stakenborg N, Wang Z, Tappe-Theodor A, Poth T, MacLaren DAA, Boeckxstaens G, Kuner R, Pitzer C, Monyer H, Xin C, Bonventre JV, Tanaka S, Voehringer D, Vanden Berghe P, Strid J, Feyerabend TB, Rodewald HR. Plum T, et al. Nature. 2023 Aug;620(7974):634-642. doi: 10.1038/s41586-023-06188-0. Epub 2023 Jul 12. Nature. 2023. PMID: 37438525 Free PMC article.

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