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Clinical Trial
. 2023 Nov 30;142(22):1932-1934.
doi: 10.1182/blood.2023021839.

Splenic iron decreases without change in volume or liver parameters during luspatercept therapy

Christopher C Denton  1   2 , Sadanand Vodala  3 , Saranya Veluswamy  1   2 , Thomas C Hofstra  1   2 , Thomas D Coates  1   2 , John C Wood  2   4
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Free article
Clinical Trial

Splenic iron decreases without change in volume or liver parameters during luspatercept therapy

Christopher C Denton et al. Blood. .
Free article

Abstract

Splenic iron decreased whereas liver iron was stable during luspatercept therapy in some individuals with thalassemia. This suggests a reduction of ineffective erythropoiesis changes the organ distribution of iron and demonstrates that liver iron concentration alone may not accurately reflect total body iron content. This article describes data from subjects enrolled in BELIEVE (NCT02604433) and BEYOND (NCT03342404).

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