. 2023 Dec;39(3):593-599.

doi: 10.1007/s12028-023-01846-7. Epub 2023 Sep 13.

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data

Collaborators, Affiliations

Collaborators

Curing Coma Campaign and its Contributing Members:
Venkatesh Aiyagari, Yama Akbari, Fawaz Al-Mufti, Sheila Alexander, Anne Alexandrov, Ayham Alkhachroum, Moshagan Amiri, Brian Appavu, Meron Awraris Gebre, Mary Kay Bader, Ram Balu, Megan Barra, Rachel Beekman, Ettore Beghi, Kathleen Bell, Tracey Berlin, Thomas Bleck, Yelena Bodien, Varina Boerwinkle, Melanie Boly, Alexandra Bonnel, Emery Brown, Eder Caceres, Elizabeth Carroll, Emilio Cediel, Sherry Chou, Giuseppe Citerio, Jan Claassen, Chad Condie, Katie Cosmas, Claire Creutzfeldt, Neha Dangayach, Michael DeGeorgia, Caroline Der-Nigoghossian, Masoom Desai, Michael Diringer, James Dullaway, Brian Edlow, Anna Estraneo, Guido Falcone, Salia Farrokh, Simona Ferioli, Davinia Fernandez-Espejo, Ericka Fink, Joseph Fins, Jennifer Frontera, Rishi Ganesan, Ahmeneh Ghavam, Joseph Giacino, Christie Gibbons, Emily Gilmore, Olivia Gosseries, Theresa Green, David Greer, Mary Guanci, Cecil Hahn, Ryan Hakimi, Flora Hammond, Daniel Hanley, Jed Hartings, Ahmed Hassan, Raimund Helbok, Claude Hemphill, H E Hinson, Karen Hirsch, Sarah Hocker, Theresa Human, David Hwang, Judy Illes, Matthew Jaffa, Michael L James, Anna Janas, Morgan Jones, Emanuela Keller, Maggie Keogh, Jenn Kim, Keri Kim, Hannah Kirsch, Matt Kirschen, Nerissa Ko, Daniel Kondziella, Natalie Kreitzer, Julie Kromm, Abhay Kumar, Pedro Kurtz, Steven Laureys, Thomas Lawson, Nicolas Lejeune, Ariane Lewis, John Liang, Geoffrey Ling, Sarah Livesay, Andrea Luppi, Lori Madden, Craig Maddux, Dea Mahanes, Shraddha Mainali, Nelson Maldonado, Rennan Martins Ribeiro, Marcello Massimini, Stephan Mayer, Victoria McCredie, Molly McNett, Jorge Mejia-Mantilla, David Menon, Julio Mijangos, Asma Moheet, Erika Molteni, Martin Monti, Chris Morrison, Susanne Muehlschlegel, Brooke Murtaugh, Lionel Naccache, Masao Nagayama, Emerson Nairon, Girija Natarajan, Virginia Newcombe, Niklas Nielsen, Naomi Niznick, Filipa Noronha-Falcão, Paul Nyquist, DaiWai Olson, Marwan Othman, Adrian Owen, Llewellyn Padayachy, Melissa Pergakis, Len Polizzotto, Nader Pouratian, Marilyn Price Spivack, Lara Prisco, Javier Provencio, Louis Puybasset, Chethan Rao, Lindsay Rasmussen, Verena Rass, Michael Reznik, Risa Richardson, Cassia Righy Shinotsuka, Courtney Robertson, Benjamin Rohaut, John Rolston, Mario Rosanova, Mary Beth Russell, Gisele Sampaio Silva, Leandro Sanz, Simone Sarasso, Aarti Sarwal, Nicolas Schiff, Caroline Schnakers, David Seder, Vishank Shah, Amy Shapiro-Rosen, Angela Shapshak, Kartavya Sharma, Tarek Sharshar, Lori Shutter, Jacobo Sitt, Beth Slomine, Wade Smith, Emmanuel Stamatakis, Alexis Steinberg, Robert Stevens, Jose Suarez, Bethany Sussman, Shaurya Taran, Aurore Thibaut, Zachary Threlkeld, Lorenzo Tinti, Daniel Toker, Michel Torbey, Stephen Trevick, Alexis Turgeon, Andrew Udy, Panos Varelas, Paul Vespa, Walter Videtta, Henning Voss, Ford Vox, Amy Wagner, John Whyte, Briana Witherspoon, Aleksandra Yakhind, Ross Zafonte, Darin Zahuranec, Chris Zammit, Bei Zhang, Wendy Ziai, Lara Zimmerman, Elizabeth Zink

Affiliations

¹ Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
² Program in Trauma, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
³ Division of Anaesthesia, University of Cambridge, Cambridge, UK.
⁴ University of Cincinnati, Cincinnati, OH, USA.
⁵ Program in Trauma, Departments of Anesthesiology and Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
⁶ School of Nursing, Emory University, Atlanta, GA, USA.
⁷ Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
⁸ Department and Laboratory of Intensive Care Medicine, University Hospitals Leuven and KU Leuven, Louvain, Belgium.
⁹ Moberg Analytics, Inc, Philadelphia, PA, USA.
¹⁰ Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Martino, Genoa, Italy.
¹¹ Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, University of Genoa, Genoa, Italy.
¹² Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
¹³ Division of Pediatric Neurology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.
¹⁴ Departments of Neurology and Biomedical Informatics, Columbia University Vagelos College of Physicians and Surgeons, NewYork-Presbyterian Hospital, New York, NY, USA. Sp3291@cumc.columbia.edu.

PMID: 37704934
PMCID: PMC10782548
DOI: 10.1007/s12028-023-01846-7

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data

Erta Beqiri et al. Neurocrit Care. 2023 Dec.

. 2023 Dec;39(3):593-599.

doi: 10.1007/s12028-023-01846-7. Epub 2023 Sep 13.

Authors

Collaborators

Curing Coma Campaign and its Contributing Members:
Venkatesh Aiyagari, Yama Akbari, Fawaz Al-Mufti, Sheila Alexander, Anne Alexandrov, Ayham Alkhachroum, Moshagan Amiri, Brian Appavu, Meron Awraris Gebre, Mary Kay Bader, Ram Balu, Megan Barra, Rachel Beekman, Ettore Beghi, Kathleen Bell, Tracey Berlin, Thomas Bleck, Yelena Bodien, Varina Boerwinkle, Melanie Boly, Alexandra Bonnel, Emery Brown, Eder Caceres, Elizabeth Carroll, Emilio Cediel, Sherry Chou, Giuseppe Citerio, Jan Claassen, Chad Condie, Katie Cosmas, Claire Creutzfeldt, Neha Dangayach, Michael DeGeorgia, Caroline Der-Nigoghossian, Masoom Desai, Michael Diringer, James Dullaway, Brian Edlow, Anna Estraneo, Guido Falcone, Salia Farrokh, Simona Ferioli, Davinia Fernandez-Espejo, Ericka Fink, Joseph Fins, Jennifer Frontera, Rishi Ganesan, Ahmeneh Ghavam, Joseph Giacino, Christie Gibbons, Emily Gilmore, Olivia Gosseries, Theresa Green, David Greer, Mary Guanci, Cecil Hahn, Ryan Hakimi, Flora Hammond, Daniel Hanley, Jed Hartings, Ahmed Hassan, Raimund Helbok, Claude Hemphill, H E Hinson, Karen Hirsch, Sarah Hocker, Theresa Human, David Hwang, Judy Illes, Matthew Jaffa, Michael L James, Anna Janas, Morgan Jones, Emanuela Keller, Maggie Keogh, Jenn Kim, Keri Kim, Hannah Kirsch, Matt Kirschen, Nerissa Ko, Daniel Kondziella, Natalie Kreitzer, Julie Kromm, Abhay Kumar, Pedro Kurtz, Steven Laureys, Thomas Lawson, Nicolas Lejeune, Ariane Lewis, John Liang, Geoffrey Ling, Sarah Livesay, Andrea Luppi, Lori Madden, Craig Maddux, Dea Mahanes, Shraddha Mainali, Nelson Maldonado, Rennan Martins Ribeiro, Marcello Massimini, Stephan Mayer, Victoria McCredie, Molly McNett, Jorge Mejia-Mantilla, David Menon, Julio Mijangos, Asma Moheet, Erika Molteni, Martin Monti, Chris Morrison, Susanne Muehlschlegel, Brooke Murtaugh, Lionel Naccache, Masao Nagayama, Emerson Nairon, Girija Natarajan, Virginia Newcombe, Niklas Nielsen, Naomi Niznick, Filipa Noronha-Falcão, Paul Nyquist, DaiWai Olson, Marwan Othman, Adrian Owen, Llewellyn Padayachy, Melissa Pergakis, Len Polizzotto, Nader Pouratian, Marilyn Price Spivack, Lara Prisco, Javier Provencio, Louis Puybasset, Chethan Rao, Lindsay Rasmussen, Verena Rass, Michael Reznik, Risa Richardson, Cassia Righy Shinotsuka, Courtney Robertson, Benjamin Rohaut, John Rolston, Mario Rosanova, Mary Beth Russell, Gisele Sampaio Silva, Leandro Sanz, Simone Sarasso, Aarti Sarwal, Nicolas Schiff, Caroline Schnakers, David Seder, Vishank Shah, Amy Shapiro-Rosen, Angela Shapshak, Kartavya Sharma, Tarek Sharshar, Lori Shutter, Jacobo Sitt, Beth Slomine, Wade Smith, Emmanuel Stamatakis, Alexis Steinberg, Robert Stevens, Jose Suarez, Bethany Sussman, Shaurya Taran, Aurore Thibaut, Zachary Threlkeld, Lorenzo Tinti, Daniel Toker, Michel Torbey, Stephen Trevick, Alexis Turgeon, Andrew Udy, Panos Varelas, Paul Vespa, Walter Videtta, Henning Voss, Ford Vox, Amy Wagner, John Whyte, Briana Witherspoon, Aleksandra Yakhind, Ross Zafonte, Darin Zahuranec, Chris Zammit, Bei Zhang, Wendy Ziai, Lara Zimmerman, Elizabeth Zink

Affiliations

¹ Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
² Program in Trauma, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
³ Division of Anaesthesia, University of Cambridge, Cambridge, UK.
⁴ University of Cincinnati, Cincinnati, OH, USA.
⁵ Program in Trauma, Departments of Anesthesiology and Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
⁶ School of Nursing, Emory University, Atlanta, GA, USA.
⁷ Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
⁸ Department and Laboratory of Intensive Care Medicine, University Hospitals Leuven and KU Leuven, Louvain, Belgium.
⁹ Moberg Analytics, Inc, Philadelphia, PA, USA.
¹⁰ Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Martino, Genoa, Italy.
¹¹ Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, University of Genoa, Genoa, Italy.
¹² Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
¹³ Division of Pediatric Neurology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.
¹⁴ Departments of Neurology and Biomedical Informatics, Columbia University Vagelos College of Physicians and Surgeons, NewYork-Presbyterian Hospital, New York, NY, USA. Sp3291@cumc.columbia.edu.

PMID: 37704934
PMCID: PMC10782548
DOI: 10.1007/s12028-023-01846-7

Erratum in

Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data.
Beqiri E, Badjatia N, Ercole A, Foreman B, Hu P, Hu X, LaRovere K, Meyfroidt G, Moberg D, Robba C, Rosenthal ES, Smielewski P, Wainwright MS, Park S; Curing Coma Campaign and its Contributing Members. Beqiri E, et al. Neurocrit Care. 2024 Feb;40(1):382-383. doi: 10.1007/s12028-023-01894-z. Neurocrit Care. 2024. PMID: 38057543 No abstract available.
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data.
Beqiri E, Badjatia N, Ercole A, Foreman B, Hu P, Hu X, LaRovere K, Meyfroidt G, Moberg D, Robba C, Rosenthal ES, Smielewski P, Wainwright MS, Park S; Curing Coma Campaign and its Contributing Members. Beqiri E, et al. Neurocrit Care. 2025 Feb;42(1):319-320. doi: 10.1007/s12028-024-02097-w. Neurocrit Care. 2025. PMID: 39187690 No abstract available.

Abstract

Background: The implementation of multimodality monitoring in the clinical management of patients with disorders of consciousness (DoC) results in physiological measurements that can be collected in a continuous and regular fashion or even at waveform resolution. Such data are considered part of the "Big Data" available in intensive care units and are potentially suitable for health care-focused artificial intelligence research. Despite the richness in content of the physiological measurements, and the clinical implications shown by derived metrics based on those measurements, they have been largely neglected from previous attempts in harmonizing data collection and standardizing reporting of results as part of common data elements (CDEs) efforts. CDEs aim to provide a framework for unifying data in clinical research and help in implementing a systematic approach that can facilitate reliable comparison of results from clinical studies in DoC as well in international research collaborations.

Methods: To address this need, the Neurocritical Care Society's Curing Coma Campaign convened a multidisciplinary panel of DoC "Physiology and Big Data" experts to propose CDEs for data collection and reporting in this field.

Results: We report the recommendations of this CDE development panel and disseminate CDEs to be used in physiologic and big data studies of patients with DoC.

Conclusions: These CDEs will support progress in the field of DoC physiologic and big data and facilitate international collaboration.

Keywords: Big Data; Coma; Common data elements; Consciousness; High-resolution data; Intensive care; Physiologic data.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest:

Erta Beqiri MD: None

Neeraj Badjatia MD MSc: None

Ari Ercole MD PhD: None

Brandon Foreman MD: Speaker for UCB Pharma, Scientific Advisory and Site PI for Marinus Pharmaceuticals, Scientific Advisory for SAGE Therapeutics, Lecturer for Natus Medical Inc

Peter Hu PhD: None

Xiao Hu PhD: Patents US10811141B2, US8634677, US10357169B2, USb8510126, US9600990B2, US20100049082, US8805703B2, US8688459; Advisory Board and Stock or stock options in Brain4Care

Kerri LaRovere MD MMSc: Patent for Emboli Detection Methods to Identify Mechanisms of Brain Injury in Susceptibe Adults and Children (Thomas Heldt et al. No: US-2022-0181008-A1).

Geert Meyfroidt MD PhD: consultant to Codman Integra

Dick Moberg: President of Moberg Analytics, Inc.

Chiara Robba MD PhD: Speaker for Masimo and Edwards

Eric Rosenthal MD: consultant to UCB Pharma; patent planned application 125141.03491

Peter Smielewski PhD: receives part of the licensing fees for ICM+ software, licensed by Cambridge Enterprise Ltd, University of Cambridge, Cambridge

Mark S. Wainwright MD PhD: Member, Neurology Clinical Advisory Board for Sage Therapeutics

Soojin Park MD: Board Trustee, Neurocritical Care Foundation; Associate Editor, Neurocritical Care

References

1. NINDS. CDE Catalog (NINDS Common Data Elements). Accessed April 10, 2023. https://www.commondataelements.ninds.nih.gov/cde-catalog}p.MsoNormal, li.MsoNormal, div.MsoNormalfont-size:12.0pt}div.WordSection1
1. Rivera Lara L, Püttgen HA. Multimodality Monitoring in the Neurocritical Care Unit. Continuum (Minneap Minn). Dec 2018;24(6):1776–1788. doi:10.1212/CON.0000000000000671 - DOI - PubMed
1. Tas J, Czosnyka M, van der Horst ICC, et al. Cerebral multimodality monitoring in adult neurocritical care patients with acute brain injury: A narrative review. Front Physiol. 2022;13:1071161. doi:10.3389/fphys.2022.1071161 - DOI - PMC - PubMed
1. Khellaf A, Khan DZ, Helmy A. Recent advances in traumatic brain injury. J Neurol. Nov 2019;266(11):2878–2889. doi:10.1007/s00415-019-09541-4 - DOI - PMC - PubMed
1. Le Roux P, Menon DK, Citerio G, et al. Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care : a statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine. Intensive Care Med. Sep 2014;40(9):1189–209. doi:10.1007/s00134-014-3369-6 - DOI - PubMed

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Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data

Collaborators

Affiliations

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data

Authors

Collaborators

Affiliations

Erratum in

Abstract

Conflict of interest statement

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources