Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep 13;21(1):621.
doi: 10.1186/s12967-023-04510-y.

Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance

Chunjie Huang  1 , Paniz Azizi  2 , Masoud Vazirzadeh  3 , Seyed Mohsen Aghaei-Zarch  4 , Fatemehsadat Aghaei-Zarch  5 , Jalaledin Ghanavi  6 , Poopak Farnia  7
Affiliations
Review

Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance

Chunjie Huang et al. J Transl Med. .

Abstract

Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helped them understand the diverse and varied nature of cancer. The altered patterns of DNA methylation found in numerous types of cancer imply that they may play a part in the disease's progression. The human cancer condition involves dysregulation of the DNA methyltransferase 3 beta (DNMT3B) gene, a prominent de novo DNA methyltransferase, and its abnormal behavior serves as an indicator for tumor prognosis and staging. The expression of non-coding RNAs (ncRNAs), which include microRNAs (miRNA), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), is critical in controlling targeted gene expression and protein translation and their dysregulation correlates with the onset of tumors. NcRNAs dysregulation of is a critical factor that influences the modulation of several cellular characteristics in cancerous cells. These characteristics include but are not limited to, drug responsiveness, angiogenesis, metastasis, apoptosis, proliferation, and properties of tumor stem cell. The reciprocal regulation of ncRNAs and DNMT3B can act in synergy to influence the destiny of tumor cells. Thus, a critical avenue for advancing cancer prevention and treatment is an inquiry into the interplay between DNMT3B and ncRNAs. In this review, we present a comprehensive overview of the ncRNAs/DNMT3B axis in cancer pathogenesis. This brings about valuable insights into the intricate mechanisms of tumorigenesis and provides a foundation for developing effective therapeutic interventions.

Keywords: Cancer; DNMT3B; Noncoding RNAs.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no competing interests.

Figures

Fig. 1
Fig. 1
A schematic representation of DNMTs regulation via non-coding RNAs
Fig. 2
Fig. 2
A schematic representation of DNMT3B location and expression
Fig. 3
Fig. 3
miRNAs significantly regulates DNMT3B in human cancer
Fig. 4
Fig. 4
CircRNAs significantly regulates DNMT3B in human cancer
Fig. 5
Fig. 5
LncRNAs significantly regulates DNMT3B in human cancer
Fig. 6
Fig. 6
DNMT3B/ncRNAs axis in cancer therapy resistance
Fig. 7
Fig. 7
Targeting DNMT3B via ncRNAs in cancer therapy
See this image and copyright information in PMC

References

    1. Peralta-Arrieta I, et al. DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation. Am J Cancer Res. 2017;7(1):77. - PMC - PubMed
    1. Shirvani H, et al. Non-coding RNA in SARS-CoV-2: progress toward therapeutic significance. Int J Biol Macromol. 2022 doi: 10.1016/j.ijbiomac.2022.09.105. - DOI - PMC - PubMed
    1. Fattahi M, et al. microRNA-382 as a tumor suppressor? Roles in tumorigenesis and clinical significance. Int J Biol Macromol. 2023 doi: 10.1016/j.ijbiomac.2023.125863. - DOI - PubMed
    1. Babakhanzadeh E, et al. Deficient expression of DGCR8 in human testis is related to spermatogenesis dysfunction, especially in meiosis I. Int J Gen Med. 2020 doi: 10.2147/IJGM.S255431. - DOI - PMC - PubMed
    1. Zarch SMA, et al. Molecular biomarkers in diabetes mellitus (DM) Med J Islam Repub Iran. 2020;34:28. doi: 10.34171/mjiri.34.28. - DOI - PMC - PubMed