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Review
. 2023 Dec;79(12):4560-4567.
doi: 10.1111/jan.15858. Epub 2023 Sep 14.

The iceberg of genomics: New perspectives in the use of genomics and epigenetics in oncology nursing clinical reasoning. A discursive paper

Alessandra Milani  1 , Eliana Misurelli  1 , Anna Giulia Bottaccioli  2   3 , Francesco Bottaccioli  2 , Silvana Lacapra  1 , Chiara Ciccarelli  1 , Giorgio Magon  4 , Ketti Mazzocco  5   6
Affiliations
Review

The iceberg of genomics: New perspectives in the use of genomics and epigenetics in oncology nursing clinical reasoning. A discursive paper

Alessandra Milani et al. J Adv Nurs. 2023 Dec.

Abstract

Background: Although, there is a wealth of information in the medical literature on the usefulness of genomic testing in assessing risk and its application in medical oncology decision making, there are no theoretical reflections in the nursing field.

Aim: To understand the implications of molecular biology in nursing practice and highlight the role of Nursing Theory in guiding nurses' reasoning.

Materials and methods: Searching literature published between 2000 and 2022 in Medline and Google Scholar. Scientific evidence was analysed by the authors expert in different fields.

Results: Based on the findings of the literature, concerns have been raised about the proper care of cancer patients who have a genomic risk profile determination. In particular, the absence of theoretical thinking and conceptual models that consider developments in molecular biology and their impact on nursing, in addition to the prevalence of heuristic thinking and the application of clinical patterns in nursing practice, could induce patient misjudgement with inadequate planning of preventive, curative, rehabilitative and educational nursing interventions. Nurses working in the field of oncology should be aware that the risk profile determined by genomics tests is merely the visible and stated portion of the cancer patient: the tip of iceberg.

Discussion: This study demonstrates how genomic testing takes into account a fraction of genes discovered in tumour tissue to establish a risk profile. This subset differs, for example, from the social genome, which can determine the risk of dementia, cancer and cardiovascular disease, but in response to social adversity. Nursing theory, which views the environment as a metaparadigm, must consider a conceptual model that can integrate the findings of genomic testing with recommendations from studies on the social genome of humans to make it easier to build nursing treatments that can better reduce these risks.

Conclusion: A nursing theoretical discourse on genomics is a paramount requirement for developing effective nursing care.

Keywords: DNA; clinical reasoning; epigenetics; genomics; oncology nursing; psychoneuroimmunology; sequence analysis; theoretical nursing.

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References

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